Mitochondria-targeting Au nanoclusters enhance radiosensitivity of cancer cells

doi:10.1039/c7tb00422b

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	Mitochondria-targeting Au nanoclusters enhance radiosensitivity of cancer cells
	Fang, X; Wang, YL; Ma, XC; Li, YY; Zhang, ZL; Xiao, ZS; Liu, LJ; Gao, XY; Liu, J; Wang YL(王亚玲)
	2017
发表期刊	JOURNAL OF MATERIALS CHEMISTRY B (IF:4.543[JCR-2016],4.787[5-Year])
ISSN	2050-750X
EISSN	2050-7518
卷号	5 期号:22 页码:4190-4197
文章类型	Article
摘要	fRadiotherapy is an important technology for the clinical treatment of cancer, but the patients suffer from the severe side effects after exposure to radiation. There is an urgent need to develop theranostic agents with excellent imaging capability and effective radiosensitization in order to minimize X-ray irradiation. Herein, we report an approach to synthesize peptide-templated Au nanoclusters (AuNCs) for theranostic radiosensitization. A new peptide (CCYKFR) is designed for the preparation of AuNCs with uniform size distribution and fluorescence (656 nm) of high photostability. CCYKFR-AuNCs feature highly efficient targeting/accumulation on mitochondria after endocytosis. With a series of experiments, we demonstrate that CCYKFR-AuNCs irradiated by 4 Gy X-rays can introduce a burst of mitoROS and severe DNA damage leading to cancer cell death. This study presents an important strategy to design theranostic nanomaterials with improved radiosensitization for the development of new anti-cancer therapies.
DOI	10.1039/c7tb00422b
关键词[WOS]	GOLD NANOPARTICLES ; X-RAY ; THERAPY ; RADIOTHERAPY ; DNA ; CLUSTERS ; MECHANISMS ; DAMAGE ; ROS ; RADIATION
收录类别	SCI ; EI ; SCOPUS
语种	英语
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
WOS记录号	WOS:000403026400019
EI入藏号	20172803923746
EI主题词	Cell death - Diseases - Molecular biology - Nanoclusters - Peptides - Radiation effects - X rays
EI分类号	461.6 Medicine and Pharmacology - 461.9 Biology - 761 Nanotechnology - 932.1 High Energy Physics - 933 Solid State Physics
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://ir.ihep.ac.cn/handle/311005/285216
专题	多学科研究中心粒子天体物理中心
作者单位	中国科学院高能物理研究所
第一作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Fang, X,Wang, YL,Ma, XC,et al. Mitochondria-targeting Au nanoclusters enhance radiosensitivity of cancer cells[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(22):4190-4197.
APA	Fang, X.,Wang, YL.,Ma, XC.,Li, YY.,Zhang, ZL.,...&王亚玲.(2017).Mitochondria-targeting Au nanoclusters enhance radiosensitivity of cancer cells.JOURNAL OF MATERIALS CHEMISTRY B,5(22),4190-4197.
MLA	Fang, X,et al."Mitochondria-targeting Au nanoclusters enhance radiosensitivity of cancer cells".JOURNAL OF MATERIALS CHEMISTRY B 5.22(2017):4190-4197.

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