Synthesis, Crystal Structure and PTPs Inhibition of a Zinc(II) Complex with N-(4-hydroxybenzyl)-L-serine

doi:10.14102/j.cnki.0254-5861.2011-1355

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	Synthesis, Crystal Structure and PTPs Inhibition of a Zinc(II) Complex with N-(4-hydroxybenzyl)-L-serine
	Li, YH; Lu, LP; Zhu, ML; Yuan, CX; Feng, SS; Gao, ZQ; Gao ZQ(高增强)
	2017
发表期刊	CHINESE JOURNAL OF STRUCTURAL CHEMISTRY结构化学 (IF:0.583[JCR-2016],0.391[5-Year])
ISSN	0254-5861
卷号	36 期号:2 页码:316-323
文章类型	Article
摘要	The reaction of the reduced Schiff base HL (N-(4-hydroxybenzyl)-L-serine) with Zn(CH3COO)(2)center dot 2H(2)O in aqueous solution afforded [Zn(L)(2)]center dot 3H(2)O (I). The complex has been characterized by elemental analysis, FT-IR, powder X-ray diffraction, electrospray ionization mass spectrometry and single-crystal X-ray diffraction. Complex I crystallizes in the orthorhombic system, space group P2(1)2(1)2(1), with a = 9.197(2), b = 10.445(2), c = 24.149(5) angstrom, V = 2319.8(8) angstrom(3), Z = 4, C20H30N2O11Zn, M-r = 539.83, D-c = 1.546 g.cm(3), mu = 1.122 mm(-1), F(000) = 1128, GOOF = 0.971, the final R = 0.0206 and wR = 0.0506 for 4346 observed reflections (I > 2 sigma(I)). In complex I, each Zn(II) ion coordinates with three carboxyl oxygen atoms and two amine nitrogen atoms from three L- anions, forming a distorted five-coordinated trigonal bipyramidal geometry. Complex I exhibits a 1D wavy chain structure that is extended by hydrogen-bonding interactions to form a supramolecular network. The bioactivity of the complex as a potential PTPs inhibitor in vitro was investigated, displaying potent inhibition against PTP1B (IC50, 0.24 mu M) and TCPTP (IC50, 0.53 mu M) with a moderate selectivity.
关键词	zinc(II) complex N-(4-hydroxybenzyl)-L-serine crystal structure inhibitory activity PTP1B TCPTP
DOI	10.14102/j.cnki.0254-5861.2011-1355
关键词[WOS]	PROTEIN-TYROSINE PHOSPHATASES ; SCHIFF-BASE ; OXOVANADIUM(IV) COMPLEXES ; DERIVATIVES ; POTENT ; ACID ; 1B
收录类别	SCI ; SCOPUS ; CSCD
语种	英语
WOS研究方向	Chemistry ; Crystallography
WOS类目	Chemistry, Inorganic & Nuclear ; Crystallography
WOS记录号	WOS:000397985700018
CSCD记录号	CSCD:5924378
引用统计	正在获取... 被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	https://ir.ihep.ac.cn/handle/311005/285188
专题	核技术应用研究中心多学科研究中心
作者单位	中国科学院高能物理研究所
第一作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Li, YH,Lu, LP,Zhu, ML,et al. Synthesis, Crystal Structure and PTPs Inhibition of a Zinc(II) Complex with N-(4-hydroxybenzyl)-L-serine[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY结构化学,2017,36(2):316-323.
APA	Li, YH.,Lu, LP.,Zhu, ML.,Yuan, CX.,Feng, SS.,...&高增强.(2017).Synthesis, Crystal Structure and PTPs Inhibition of a Zinc(II) Complex with N-(4-hydroxybenzyl)-L-serine.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY结构化学,36(2),316-323.
MLA	Li, YH,et al."Synthesis, Crystal Structure and PTPs Inhibition of a Zinc(II) Complex with N-(4-hydroxybenzyl)-L-serine".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY结构化学 36.2(2017):316-323.