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Biomimetic construction of protein-conjugated gold clusters for detecting Hg2+
He, J; Liu, MQ; Gao FP(高福平); Gao J(高靓); Gao XY(高学云); Gao, FP; Gao, L; Gao, XY; Han, R
2017
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
EISSN1873-4359
Volume518Pages:80-84
SubtypeArticle
AbstractMercury ion (Hg2+) pollution has deleterious effects on the environment and human health. Herein, through one-step biomimetic mineralization of metal salt with a natural protein, we develop an optical sensor system for Hg2+ detection with high selectivity and sensitivity. Glucose oxidase (GOD) serves as both a template and reducing agent to achieve the in situ biomineralization of Au (III), producing stable fluorescent GOD-conjugated gold clusters (GOD-AuCs) with a high yield. The probe above with a uniform core size of around 2.5 nm, has an obvious maximum fluorescence emission peak at 686 nm. GOD-AuCs exhibit good selectivity to Hg2+, in comparison to other metal ions including K+, Na+, Ca2+, Mg2+, Zn2+ and Cu2+. The reason might be that the existence of a small amount of Au+ (21%) on the surface of the cluster, permits strong metallophilic interaction between GOD-AuCs and Hg2+. It results in the instantaneous and remarkable fluorescence quench. Moreover, the intensity of fluorescence quench is found to be linearly depended on the concentration of Hg2+, with a detection limit of 7.5 mu M. These favorable findings promise GOD-AuCs have a good potential in monitoring environmental Hg2+. (C) 2017 Elsevier B.V. All rights reserved.
KeywordMetal cluster Biomineralization Fluorescence probe Hg2+
DOI10.1016/j.colsurfa.2017.01.018
WOS KeywordBIOMEDICAL APPLICATIONS ; METAL NANOCLUSTERS ; AU NANOCLUSTERS ; CANCER
Indexed BySCI ; EI ; SCOPUS
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
WOS IDWOS:000395842900010
EI Accession Number20170303257781
EI KeywordsBiomimetics - Biomineralization - Fluorescence - Glucose oxidase - Glucose sensors - Gold - Metal ions - Probes
EI Classification Number461.9 Biology - 462.1 Biomedical Equipment, General - 531.1 Metallurgy - 547.1 Precious Metals - 741.1 Light/Optics
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285178
Collection多学科研究中心
加速器中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
He, J,Liu, MQ,Gao FP,et al. Biomimetic construction of protein-conjugated gold clusters for detecting Hg2+[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2017,518:80-84.
APA He, J.,Liu, MQ.,高福平.,高靓.,高学云.,...&Han, R.(2017).Biomimetic construction of protein-conjugated gold clusters for detecting Hg2+.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,518,80-84.
MLA He, J,et al."Biomimetic construction of protein-conjugated gold clusters for detecting Hg2+".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 518(2017):80-84.
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