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Metallofullerenol Inhibits Cellular Iron Uptake by Inducing Transferrin Tetramerization
Li JX(李金霞); Xing XQ(邢雪青); Sun BY(孙宝云); Zhao YL(赵宇亮); Wu ZH(吴忠华); Li, J., X. Xing, B. Sun, Y. Zhao and Z. Wu
2017
Source PublicationCHEMISTRY-AN ASIAN JOURNAL
ISSN1861-4728
EISSN1861-471X
Volume12Issue:20Pages:2646-2651
SubtypeArticle
AbstractHerein, A549 tumor cell proliferation was confirmed to be positively dependent on the concentration of Fe3+ or transferrin (Tf). Gd@C-82(OH)(22) or C-60(OH)(22) effectively inhibited the iron uptake and the subsequent proliferation of A549 cells. The conformational changes of Tf mixed with FeCl3, GdCl3, C-60(OH)(22) or Gd@C-82(OH)(22) were obtained by SAXS. The results demonstrate that Tf homodimers can be decomposed into monomers in the presence of FeCl3, GdCl3 or C-60(OH)(22), but associated into tetramers in the presence of Gd@C-82(OH)(22). The larger change of SAXS shapes between Tf+C-60(OH)(22) and Tf+FeCl3 implies that C-60(OH)(22) is bound to Tf, blocking the iron-binding site. The larger deviation of the SAXS shape from a possible crystal structure of Tf tetramer implies that Gd@C-82(OH)(22) is bound to the Tf tetramer, thus disturbing iron transport. This study well explains the inhibition mechanism of Gd@C-82(OH)(22) and C-60(OH)(22) on the iron uptake and the proliferation of A549 tumor cells and highlights the specific interactions of a nanomedicine with the target biomolecules in cancer therapy.
Keywordcancer therapy iron uptake nanomedicine small-angle X-ray scattering transferrin
DOI10.1002/asia.201700910
WOS KeywordSMALL-ANGLE SCATTERING ; X-RAY-SCATTERING ; BIOLOGICAL MACROMOLECULES ; FULLERENE DERIVATIVES ; NANOPARTICLES ; CANCER ; GD-AT-C-82(OH)(22) ; ACTIVATION ; PROLIFERATION ; NANOMEDICINE
Indexed BySCI ; EI ; PUBMED ; MEDLINE ; SCOPUS
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000413354300003
EI Accession Number20174304293169
EI KeywordsCell proliferation - Chlorine compounds - Crystal structure - Diseases - Iron - Iron compounds - Medical nanotechnology - Oligomers - Oncology - Tumors - X ray scattering
EI Classification Number461 Bioengineering and Biology - 545.1 Iron - 761 Nanotechnology - 815.1.1 Organic Polymers - 932.1 High Energy Physics - 933.1.1 Crystal Lattice
MedlineIDMEDLINE:28815927
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285083
Collection多学科研究中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Li JX,Xing XQ,Sun BY,et al. Metallofullerenol Inhibits Cellular Iron Uptake by Inducing Transferrin Tetramerization[J]. CHEMISTRY-AN ASIAN JOURNAL,2017,12(20):2646-2651.
APA 李金霞,邢雪青,孙宝云,赵宇亮,吴忠华,&Li, J., X. Xing, B. Sun, Y. Zhao and Z. Wu.(2017).Metallofullerenol Inhibits Cellular Iron Uptake by Inducing Transferrin Tetramerization.CHEMISTRY-AN ASIAN JOURNAL,12(20),2646-2651.
MLA 李金霞,et al."Metallofullerenol Inhibits Cellular Iron Uptake by Inducing Transferrin Tetramerization".CHEMISTRY-AN ASIAN JOURNAL 12.20(2017):2646-2651.
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