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Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase
Gao FP(高福平); Gao J(高靓); Cai PJ(蔡鹏举); Liu R(刘茹); Wang YL(王亚玲); Yuan Q(袁泉); Zhao YL(赵宇亮); Gao XY(高学云); Gao, FP; Zheng, WP; Gao, L; Cai, PJ; Liu, R; Wang, YL; Yuan, Q; Zhao, YL; Gao, XY
2017
Source PublicationADVANCED HEALTHCARE MATERIALS
ISSN2192-2640
EISSN2192-2659
Volume6Issue:7Pages:1601453
SubtypeArticle
AbstractPhotodynamic therapy (PDT) is a minimally invasive therapeutic procedure of tumors with high selectivity and low side effect. However, it is usually not efficient in long-lasting tumor control. One of the main reasons is tumor cells develop some protective mechanisms that help them to deal with oxidative stress in the environment. The thioredoxin system in cancer is an important antioxidant defense system. Au nanoclusters could effectively inhibit thioredoxin reductase (TrxR) in tumor cell cytoplasm. Herein, Au nanoclusters and photosensitizer Chlorine 6 (Ce6) are co-loaded in spatiotemporal controllable liposomal nanocomposites. pH responsive molecule inserted in lipid bilayer greatly contributes to the instability of the lipid membrane in lysosomal at low pH environment. Then the payloads can rapidly release into cytoplasm. Au nanoclusters effectively inhibit TrxR in cytoplasm and enhance the photodynamic-induced intracellular reactive oxygen-free radical concentration, improving the effect of PDT. Breast cancer is chosen as a tumor model and the Au nanoclusters and photosensitizer co-loaded liposomal nanocomposites are studied to improve the effect of PDT both in vitro and in vivo, and its corresponding mechanism is investigated. This study develops a new application of gold nanoclusters and provides a new train of thoughts for enhancing the effect of PDT.
DOI10.1002/adhm.201601453
WOS KeywordOVARIAN-CANCER ; DRUG-RELEASE ; CELLS ; MECHANISMS ; APOPTOSIS ; SENSITIVITY ; EXPRESSION ; RESISTANCE ; VESICLES ; STRESS
Indexed BySCI ; PUBMED ; SCOPUS
Language英语
WOS Research AreaEngineering ; Science & Technology - Other Topics ; Materials Science
WOS SubjectEngineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS IDWOS:000399719900012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/284963
Collection多学科研究中心
粒子天体物理中心
管理与技术支持
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Gao FP,Gao J,Cai PJ,et al. Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase[J]. ADVANCED HEALTHCARE MATERIALS,2017,6(7):1601453.
APA 高福平.,高靓.,蔡鹏举.,刘茹.,王亚玲.,...&Gao, XY.(2017).Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase.ADVANCED HEALTHCARE MATERIALS,6(7),1601453.
MLA 高福平,et al."Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase".ADVANCED HEALTHCARE MATERIALS 6.7(2017):1601453.
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