| Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase | |
Gao FP(高福平) ; Gao J(高靓); Cai PJ(蔡鹏举); Liu R(刘茹); Wang YL(王亚玲); Yuan Q(袁泉); Zhao YL(赵宇亮); Gao XY(高学云); Gao, FP; Zheng, WP; Gao, L; Cai, PJ; Liu, R; Wang, YL; Yuan, Q; Zhao, YL; Gao, XY
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| 2017 | |
| Source Publication | ADVANCED HEALTHCARE MATERIALS
 |
| ISSN | 2192-2640 |
| EISSN | 2192-2659 |
| Volume | 6Issue:7Pages:1601453 |
| Subtype | Article |
| Abstract | Photodynamic therapy (PDT) is a minimally invasive therapeutic procedure of tumors with high selectivity and low side effect. However, it is usually not efficient in long-lasting tumor control. One of the main reasons is tumor cells develop some protective mechanisms that help them to deal with oxidative stress in the environment. The thioredoxin system in cancer is an important antioxidant defense system. Au nanoclusters could effectively inhibit thioredoxin reductase (TrxR) in tumor cell cytoplasm. Herein, Au nanoclusters and photosensitizer Chlorine 6 (Ce6) are co-loaded in spatiotemporal controllable liposomal nanocomposites. pH responsive molecule inserted in lipid bilayer greatly contributes to the instability of the lipid membrane in lysosomal at low pH environment. Then the payloads can rapidly release into cytoplasm. Au nanoclusters effectively inhibit TrxR in cytoplasm and enhance the photodynamic-induced intracellular reactive oxygen-free radical concentration, improving the effect of PDT. Breast cancer is chosen as a tumor model and the Au nanoclusters and photosensitizer co-loaded liposomal nanocomposites are studied to improve the effect of PDT both in vitro and in vivo, and its corresponding mechanism is investigated. This study develops a new application of gold nanoclusters and provides a new train of thoughts for enhancing the effect of PDT. |
| DOI | 10.1002/adhm.201601453 |
| WOS Keyword | OVARIAN-CANCER ; DRUG-RELEASE ; CELLS ; MECHANISMS ; APOPTOSIS ; SENSITIVITY ; EXPRESSION ; RESISTANCE ; VESICLES ; STRESS |
| Indexed By | SCI ; PUBMED ; SCOPUS |
| Language | 英语 |
| WOS Research Area | Engineering ; Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials |
| WOS ID | WOS:000399719900012 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/284963 |
| Collection | 多学科研究中心 粒子天体物理中心 管理与技术支持 |
| Affiliation | 中国科学院高能物理研究所 |
| First Author Affilication | Institute of High Energy |
| Recommended Citation GB/T 7714 | Gao FP,Gao J,Cai PJ,et al. Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase[J]. ADVANCED HEALTHCARE MATERIALS,2017,6(7):1601453. |
| APA | 高福平.,高靓.,蔡鹏举.,刘茹.,王亚玲.,...&Gao, XY.(2017).Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase.ADVANCED HEALTHCARE MATERIALS,6(7),1601453. |
| MLA | 高福平,et al."Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase".ADVANCED HEALTHCARE MATERIALS 6.7(2017):1601453. |
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