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Iron-induced generation of mitochondrial ROS depends on AMPK activity
Huang H(黄辉); Chen J(陈俊); Lu HR(卢会茹); Zhou MX(周梦雪); Chai ZF(柴之芳); Hu Y(胡毅); Huang, H; Chen, J; Lu, HR; Zhou, MX; Chai, ZF; Hu, Y
2017
Source PublicationBIOMETALS
ISSN0966-0844
EISSN1572-8773
Volume30Issue:4Pages:623-628
SubtypeArticle
AbstractDeregulated iron homeostasis is generally believed to be implicated in neurodegenerative diseases, including Parkinson's disease. Nevertheless, it is not fully understood how iron overload can elicit neuronal cell damage. Here we examined mitochondrial reactive oxygen species (ROS) levels in human dopaminergic neuroblastoma SH-SY5Y cells upon iron exposure. A relatively high concentration of iron could significantly increase mitochondrial ROS levels in SH-SY5Y cells. Pharmacological activation of AMP-activated protein kinase (AMPK) almost completely inhibited the effect of iron on mitochondrial ROS. By contrast, AMPK inhibition aggravated the neurotoxicity of iron and enhanced the production of mitochondrial ROS. Collectively, these findings suggested that excess iron may be able to perturb mitochondrial function, and AMPK activity is important for the association of iron and mitochondria.
KeywordFe(II) AMPK Neurotoxicity Mitochondria ROS
DOI10.1007/s10534-017-0023-0
WOS KeywordPARKINSONS-DISEASE ; SH-SY5Y CELLS ; NEUROTOXICITY ; STRESS ; MTOR ; DRUG
Indexed BySCI ; PUBMED ; MEDLINE ; SCOPUS
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000405780200014
MedlineIDMEDLINE:28608291
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/284953
Collection多学科研究中心
实验物理中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Huang H,Chen J,Lu HR,et al. Iron-induced generation of mitochondrial ROS depends on AMPK activity[J]. BIOMETALS,2017,30(4):623-628.
APA 黄辉.,陈俊.,卢会茹.,周梦雪.,柴之芳.,...&Hu, Y.(2017).Iron-induced generation of mitochondrial ROS depends on AMPK activity.BIOMETALS,30(4),623-628.
MLA 黄辉,et al."Iron-induced generation of mitochondrial ROS depends on AMPK activity".BIOMETALS 30.4(2017):623-628.
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