| Iron-induced generation of mitochondrial ROS depends on AMPK activity | |
Huang H(黄辉); Chen J(陈俊) ; Lu HR(卢会茹); Zhou MX(周梦雪); Chai ZF(柴之芳); Hu Y(胡毅); Huang, H; Chen, J; Lu, HR; Zhou, MX; Chai, ZF; Hu, Y
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| 2017 | |
| Source Publication | BIOMETALS
 |
| ISSN | 0966-0844 |
| EISSN | 1572-8773 |
| Volume | 30Issue:4Pages:623-628 |
| Subtype | Article |
| Abstract | Deregulated iron homeostasis is generally believed to be implicated in neurodegenerative diseases, including Parkinson's disease. Nevertheless, it is not fully understood how iron overload can elicit neuronal cell damage. Here we examined mitochondrial reactive oxygen species (ROS) levels in human dopaminergic neuroblastoma SH-SY5Y cells upon iron exposure. A relatively high concentration of iron could significantly increase mitochondrial ROS levels in SH-SY5Y cells. Pharmacological activation of AMP-activated protein kinase (AMPK) almost completely inhibited the effect of iron on mitochondrial ROS. By contrast, AMPK inhibition aggravated the neurotoxicity of iron and enhanced the production of mitochondrial ROS. Collectively, these findings suggested that excess iron may be able to perturb mitochondrial function, and AMPK activity is important for the association of iron and mitochondria. |
| Keyword | Fe(II) AMPK Neurotoxicity Mitochondria ROS |
| DOI | 10.1007/s10534-017-0023-0 |
| WOS Keyword | PARKINSONS-DISEASE ; SH-SY5Y CELLS ; NEUROTOXICITY ; STRESS ; MTOR ; DRUG |
| Indexed By | SCI ; PUBMED ; MEDLINE ; SCOPUS |
| Language | 英语 |
| WOS Research Area | Biochemistry & Molecular Biology |
| WOS Subject | Biochemistry & Molecular Biology |
| WOS ID | WOS:000405780200014 |
| MedlineID | MEDLINE:28608291 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/284953 |
| Collection | 多学科研究中心 实验物理中心 |
| Affiliation | 中国科学院高能物理研究所 |
| First Author Affilication | Institute of High Energy |
| Recommended Citation GB/T 7714 | Huang H,Chen J,Lu HR,et al. Iron-induced generation of mitochondrial ROS depends on AMPK activity[J]. BIOMETALS,2017,30(4):623-628. |
| APA | 黄辉.,陈俊.,卢会茹.,周梦雪.,柴之芳.,...&Hu, Y.(2017).Iron-induced generation of mitochondrial ROS depends on AMPK activity.BIOMETALS,30(4),623-628. |
| MLA | 黄辉,et al."Iron-induced generation of mitochondrial ROS depends on AMPK activity".BIOMETALS 30.4(2017):623-628. |
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