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Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies
Liu MQ(刘梅青); Gao J(高靓); Zhao LN(赵丽娜); He J(贺剑); Yuan Q(袁卿); Zhang P(张鹏); Zhao YW(赵亚伟); Gao XY(高学云); Liu, MQ; Gao, L; Zhao, LN; He, J; Yuan, Q; Zhang, P; Zhao, YW; Gao, XY
2017
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume7Pages:131
SubtypeArticle
AbstractThe original motivation of the article is to give a systematic investigation on the protocol of combining computer simulation and accurate synthesis of serial peptide protected gold clusters for potent tumor targeting therapy. Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant selenoenzyme that regulates cellular redox level, thus becomes a potential target in cancer treatment. We firstly utilize molecular dynamic ( MD) simulation to rationally design and screen serial peptide-Au cluster compounds with special peptide sequences and precise gold atoms, which can recognize and bind specific domain of GPx-1 with high affinity. The theoretical simulations were further verified by the following peptide-Au clusters synthesis and GPx-1 activity suppression studies in buffer and cells, respectively. Further cytological experiments corroborated that peptide-Au clusters are promising nanoparticles inducing tumor cells apoptosis by suppressing GPx-1 activity and increasing higher cellular reactive oxygen species level to initiate tumor cell apoptosis through intrinsic mitochondrial pathway.
DOI10.1038/s41598-017-00278-6
WOS KeywordPROTEIN-NANOPARTICLE INTERACTIONS ; MEDIATED MITOCHONDRIAL PATHWAY ; METAL NANOCLUSTERS ; OPTICAL-PROPERTIES ; CHEMICAL-SYNTHESIS ; GOLD NANOCLUSTERS ; ATOMIC PRECISION ; QUANTUM DOTS ; CANCER-CELLS ; INHIBITION
Indexed BySCI ; PUBMED ; MEDLINE ; SCOPUS ; ADS
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000396868900013
ADS Bibcode2017NatSR...7..131L
ADS URLhttps://ui.adsabs.harvard.edu/abs/2017NatSR...7..131L
ADS CITATIONShttps://ui.adsabs.harvard.edu/abs/2017NatSR...7..131L/citations
MedlineIDMEDLINE:28273930
Citation statistics
Cited Times:2 [ADS]
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/284860
Collection多学科研究中心
加速器中心
粒子天体物理中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Liu MQ,Gao J,Zhao LN,et al. Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies[J]. SCIENTIFIC REPORTS,2017,7:131.
APA 刘梅青.,高靓.,赵丽娜.,贺剑.,袁卿.,...&Gao, XY.(2017).Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies.SCIENTIFIC REPORTS,7,131.
MLA 刘梅青,et al."Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies".SCIENTIFIC REPORTS 7(2017):131.
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