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Multifunctional thermoresponsive designer peptide hydrogels
De Leon-Rodriguez, Luis M.1; Hemar, Yacine2; Mo G(默广)3; Mo, Guang3; Mitra, Alok K.1; Cornish, Jillian4; Brimble, Margaret A.1,2
2017
Source PublicationACTA BIOMATERIALIA
ISSN1742-7061
Volume47Pages:40-49
Corresponding AuthorDe Leon-Rodriguez, Luis M.(l.deleon@auckland.ac.nz) ; Brimble, Margaret A.(m.brim-ble@auckland.ac.nz)
AbstractWe report the synthesis and characterization of multifunctional peptides comprised of a hydrogel forming beta-sheet peptide segment and a matrix metalloproteinase 2 substrate containing a propargylglycinyl linker that is further derivatized with an RGD peptide sequence via "click" chemistry. In contrast to currently known systems, these multifunctional peptides formed gels that are stiffer than those formed by their respective precursors. All the peptides showed reversible thermoresponsive properties, which render them as suitable lead systems for a variety of possible biomedical applications. Statement of Significance In general, it has been frequently observed that chemical biofunctionalization of peptide hydrogels adversely affects peptide assembly, hydrogel formation or mechanical properties, which severely compromises their application. A functionalization protocol that allows to generate peptide hydrogels that display significantly improved mechanical properties over their unfunctionalized counterparts is reported in this work. These peptides also showed thermoresponsive viscoelastic characteristics, including an example of a peptide hydrogel that displays lower critical solution temperature behaviour. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
KeywordPeptide Hydrogel Thermoresponsive Adhesion Enzymatic-cleavage Mechanical characterization
DOI10.1016/j.actbio.2016.10.014
WOS KeywordSELF-ASSEMBLING BIOMATERIALS ; MESENCHYMAL STEM-CELLS ; BETA-SHEET PEPTIDES ; RATIONAL DESIGN ; POLYPEPTIDE ; MATRICES ; SCAFFOLDS ; THERMOGEL ; SYSTEMS
Indexed BySCI ; MEDLINE ; SCOPUS
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000389102600004
PublisherELSEVIER SCI LTD
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/281848
Collection中国科学院高能物理研究所
Affiliation1.Univ Auckland, Sch Biol Sci, 3A Symonds St,Thomas Bldg, Auckland 1010, New Zealand;
2.Univ Auckland, Sch Chem Sci, 23 Symonds St, Auckland 1010, New Zealand;
3.Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing, Peoples R China;
4.Univ Auckland, Dept Med, Auckland, New Zealand
Recommended Citation
GB/T 7714
De Leon-Rodriguez, Luis M.,Hemar, Yacine,Mo G,et al. Multifunctional thermoresponsive designer peptide hydrogels[J]. ACTA BIOMATERIALIA,2017,47:40-49.
APA De Leon-Rodriguez, Luis M..,Hemar, Yacine.,默广.,Mo, Guang.,Mitra, Alok K..,...&Brimble, Margaret A..(2017).Multifunctional thermoresponsive designer peptide hydrogels.ACTA BIOMATERIALIA,47,40-49.
MLA De Leon-Rodriguez, Luis M.,et al."Multifunctional thermoresponsive designer peptide hydrogels".ACTA BIOMATERIALIA 47(2017):40-49.
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