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The neurotoxicity of iron, copper and cobalt in Parkinson's disease through ROS-mediated mechanisms
Lan AP(兰爱平); Chen J(陈俊); Chai ZF(柴之芳); Hu Y(胡毅); Lan, AP; Chen, J; Chai, ZF; Hu, Y
2016
发表期刊BIOMETALS
卷号29期号:4页码:665
通讯作者胡毅
文章类型Article
摘要Parkinson's disease (PD) is the second most common neurodegenerative disease with gradual loss of dopaminergic neurons. Despite extensive research in the past decades, the etiology of PD remains elusive. Nevertheless, multiple lines of evidence suggest that oxidative stress is one of the common causes in the pathogenesis of PD. It has also been suggested that heavy metal-associated oxidative stress may be implicated in the etiology and pathogenesis of PD. Here we review the roles of redox metals, including iron, copper and cobalt, in PD. Iron is a highly reactive element and deregulation of iron homeostasis is accompanied by concomitant oxidation processes in PD. Copper is a key metal in cell division process, and it has been shown to have an important role in neurodegenerative diseases such as PD. Cobalt induces the generation of reactive oxygen species (ROS) and DNA damage in brain tissues.
关键词Parkinson's disease Reactive oxygen species Iron Copper Cobalt
DOI10.1007/s10534-016-9942-4
关键词[WOS]INDUCED OXIDATIVE STRESS ; ENDOTHELIN-2/VASOACTIVE INTESTINAL CONTRACTOR ; CHLORIDE-INDUCED APOPTOSIS ; DOPAMINE NEURON DEGENERATION ; ALPHA-SYNUCLEIN AGGREGATION ; ACTIVATED PROTEIN-KINASE ; HYPOXIA-INDUCED INJURY ; X-RAY-MICROANALYSIS ; N-SH CELLS ; PC12 CELLS
语种英语
WOS记录号WOS:000381144200008
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/261076
专题院士
多学科研究中心
作者单位中国科学院高能物理研究所
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Lan AP,Chen J,Chai ZF,et al. The neurotoxicity of iron, copper and cobalt in Parkinson's disease through ROS-mediated mechanisms[J]. BIOMETALS,2016,29(4):665.
APA 兰爱平.,陈俊.,柴之芳.,胡毅.,Lan, AP.,...&Hu, Y.(2016).The neurotoxicity of iron, copper and cobalt in Parkinson's disease through ROS-mediated mechanisms.BIOMETALS,29(4),665.
MLA 兰爱平,et al."The neurotoxicity of iron, copper and cobalt in Parkinson's disease through ROS-mediated mechanisms".BIOMETALS 29.4(2016):665.
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