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Crossover between Anti- and Pro-oxidant Activities of Graphene Quantum Dots in the Absence or Presence of Light
Chong, Y; Ge, CC; Fang, G; Tian, X; Ma, XC; Wen, T; Wamer, WG; Chen, CY; Chai, ZF; Yin, JJ; Chen CY(陈春英); Chai ZF(柴之芳)
2016
发表期刊ACS NANO
卷号10期号:9页码:8690
文章类型Article
摘要Graphene quantum dots (GQDs), zero dimensional carbon materials displaying excellent luminescence properties, show great promise for medical applications such as imaging, drug delivery, biosensors, and novel therapeutics. A deeper understanding of how the properties of GQDs interact with biological systems is essential for these applications. Our work demonstrates that GQDs can efficiently scavenge a number of free radicals and thereby protect cells against oxidative damage. However, upon exposure to blue light, GQDs exhibit significant phototoxicity through increasing intracellular reactive oxygen species (ROS) levels and reducing cell viability, attributable to the generation of free radicals under light excitation. We confirm that light-induced formation of ROS originates from the electron-hole pair and, more importantly, reveal that singlet oxygen is generated by photoexcited GQDs via both energy-transfer and electron-transfer pathways. Moreover, upon light excitation, GQDs accelerate the oxidation of non-enzymic anti-oxidants and promote lipid peroxidation, contributing to the phototoxicity of GQDs. Our results reveal that GQDs can display both anti- and pro-oxidant activities, depending upon light exposure, which will be useful in guiding the safe application and development of potential anticancer/antibacterial applications for GQDs.
关键词graphene quantum dots free radicals anti-oxidants phototoxicity lipid peroxidation
DOI10.1021/acsnano.6b04061
关键词[WOS]SINGLET OXYGEN GENERATION ; OXIDATIVE STRESS ; ASCORBIC-ACID ; FREE-RADICALS ; CARBON DOTS ; SUPEROXIDE ; CONVERSION ; ANTIOXIDANTS ; MECHANISMS ; CHEMISTRY
语种英语
WOS记录号WOS:000384399300062
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/261069
专题院士
作者单位中国科学院高能物理研究所
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Chong, Y,Ge, CC,Fang, G,et al. Crossover between Anti- and Pro-oxidant Activities of Graphene Quantum Dots in the Absence or Presence of Light[J]. ACS NANO,2016,10(9):8690.
APA Chong, Y.,Ge, CC.,Fang, G.,Tian, X.,Ma, XC.,...&柴之芳.(2016).Crossover between Anti- and Pro-oxidant Activities of Graphene Quantum Dots in the Absence or Presence of Light.ACS NANO,10(9),8690.
MLA Chong, Y,et al."Crossover between Anti- and Pro-oxidant Activities of Graphene Quantum Dots in the Absence or Presence of Light".ACS NANO 10.9(2016):8690.
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