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Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy
Gao, H; Bi Y(毕颖); Chen J(陈俊); Wen KK(温凯凯); Chai ZF(柴之芳); Hu Y(胡毅); Bi, Y; Chen, J; Peng, LR; Wen, KK; Ji, P; Ren, WF; Li, XQ; Zhang, N; Gao, JM; Chai, ZF; Hu, Y
2016
发表期刊ACS APPLIED MATERIALS & INTERFACES
卷号8期号:24页码:15103
通讯作者胡毅
文章类型Article
摘要Accumulation of nanoparticles in solid tumors depends on their extravasation, but their efficacy is often compromised by intrinsic physiological heterogeneity in tumors. The conventional solutions to circumvent this problem are size control of nanoparticles or increasing the vascular permeability. The aim of this study is to investigate the combination effect of size variation of stimuli-responsive nanoparticles and improved vascular permeability triggered by near-infrared (NIR) light irradiation. Doxorubicin (DOX), a clinically proven drug for bladder cancer, was encapsulated in the nanocomposites with high loading content up to 45%. We show that NIR light-responsive size-switchable nanocarriers could considerably enhance the tumor-targeting of DOX in bladder tumor-bearing mice. Moreover, a combination of NIR-induced hyperthermia and DOXmediated chemotherapy resulted in remarkable inhibition of tumor growth in mice. Histological results suggest that the change in morphology of tumor microvasculature may account for enhanced extravasation and accumulation of the nanodrugs upon NIR irradiation. Together, these data suggest that external stimuli-responsive drug delivery system offers a safe and effective means of targeted chemo/photothermal therapy.
关键词stimuli-responsive nanoparticles size-switchable chemo/photothermal therapy vascular permeability
DOI10.1021/acsami.6b03905
关键词[WOS]ANTICANCER DRUG-DELIVERY ; PHOTOSWITCHABLE NANOPARTICLES ; MACROMOLECULAR THERAPEUTICS ; DOXORUBICIN DELIVERY ; PH ; NANOMEDICINE ; NANOCARRIERS ; MICELLES ; TISSUE ; PERMEABILITY
语种英语
WOS记录号WOS:000378584800025
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/261062
专题院士
多学科研究中心
作者单位中国科学院高能物理研究所
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Gao, H,Bi Y,Chen J,et al. Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(24):15103.
APA Gao, H.,毕颖.,陈俊.,温凯凯.,柴之芳.,...&Hu, Y.(2016).Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy.ACS APPLIED MATERIALS & INTERFACES,8(24),15103.
MLA Gao, H,et al."Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy".ACS APPLIED MATERIALS & INTERFACES 8.24(2016):15103.
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