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Synthesis and biological studies of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) as a novel tumor imaging agent
Wang JJ(汪建军); Yang WJ(杨文江); Xue JQ(薛井泉); Zhang YH(张延华); Han WW(韩维伟); Liu Y(刘宇); Wang, J; Yang, W; Xue, J; Zhang, Y; Han, W; Liu, Y
2016
发表期刊JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
卷号310期号:3页码:1209-1213
通讯作者汪建军 ; 刘宇(多)
摘要This work reports the synthesis, radiolabeling and biological studies of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) in tumor-bearing mice. The novel melphalan derivative was successfully synthesized by conjugation of HYNIC to melphalan. The ligand could be labeled by Tc-99m in high yield to get Tc-99m(HYNIC-MFL)(tricine)(TPPTS), which was very hydrophilic and was stable at room temperature. Biodistribution studies in tumor-bearing mice showed that Tc-99m(HYNIC-MFL)(tricine)(TPPTS) accumulated in the tumor with favorable uptake and retention. The good accumulation in tumor tissue, high tumor/muscle ratios and satisfactory scintigraphic images highlight the potential of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) for tumor imaging.
文章类型期刊论文
关键词Tc-99m(HYNIC-MFL)(tricine)(TPPTS) Melphalan Label Tumor imaging
DOI10.1007/s10967-016-4955-6
关键词[WOS]RADIOPHARMACEUTICALS ; DNA
WOS类目Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology
WOS记录号WOS:000388629900030
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文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260536
专题核技术应用研究中心
多学科研究中心
作者单位中国科学院高能物理研究所
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Wang JJ,Yang WJ,Xue JQ,et al. Synthesis and biological studies of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) as a novel tumor imaging agent[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2016,310(3):1209-1213.
APA 汪建军.,杨文江.,薛井泉.,张延华.,韩维伟.,...&Liu, Y.(2016).Synthesis and biological studies of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) as a novel tumor imaging agent.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,310(3),1209-1213.
MLA 汪建军,et al."Synthesis and biological studies of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) as a novel tumor imaging agent".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 310.3(2016):1209-1213.
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