Early Non-invasive Detection of Acute 1,2-Dichloroethane-induced Toxic Encephalopathy in Rats
Zhou, XL; Cao, YZ; Leuze, C; Nie, BB; Shan, BC; Zhou, WB; Cipriano, P; Xiao, B; Nie BB(聂彬彬); Dan BC(单保慈)
刊名IN VIVO
2016
卷号30期号:6页码:787
关键词1,2-Dichloroethane exposure diffusion magnetic resonance imaging brain edema toxic encephalopathy
DOI10.21873/invivo.10995
文章类型期刊论文
英文摘要Aim: To assess the acute effect of 1,2-dichloroethane (1,2-DCE) on rat brain using diffusion magnetic resonance imaging (dMRI). Materials and Methods: We performed dMRI on 30 male Sprague-Dawley rats, microstructural alterations were investigated by calculating the mean fractional anisotropy (FA) and apparent diffusion coefficient (ADC) changes in eight selected brain regions of interest. For the whole brain, clusters of 20+ voxels that differed significantly in FA and ADC between groups were marked. Hematoxylin-eosin staining was performed to confirm pathological changes. Results: Brain images showed lesions with brain edema in the white matter in both hemispheres in all groups exposed to 1,2-DCE. Diffusivity values were significantly different after 1,2-DCE inhalation (p<0.05). Conclusion: Primarily cytotoxic edema occurred in acute 1,2-DCE-induced brain edema in rats. dMRI could be used for the early non-invasive detection of acute 1,2-DCE-induced toxic encephalopathy.
类目[WOS]Medicine, Research & Experimental
关键词[WOS]BRAIN ; EXPOSURE ; INJURY ; EDEMA
WOS记录号WOS:000392926200009
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260527
专题中国科学院高能物理研究所_核技术应用研究中心_期刊论文
作者单位中国科学院高能物理研究所
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GB/T 7714
Zhou, XL,Cao, YZ,Leuze, C,et al. Early Non-invasive Detection of Acute 1,2-Dichloroethane-induced Toxic Encephalopathy in Rats[J]. IN VIVO,2016,30(6):787.
APA Zhou, XL.,Cao, YZ.,Leuze, C.,Nie, BB.,Shan, BC.,...&单保慈.(2016).Early Non-invasive Detection of Acute 1,2-Dichloroethane-induced Toxic Encephalopathy in Rats.IN VIVO,30(6),787.
MLA Zhou, XL,et al."Early Non-invasive Detection of Acute 1,2-Dichloroethane-induced Toxic Encephalopathy in Rats".IN VIVO 30.6(2016):787.
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