Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging
Tang, X; Wu, D; Gu, LH; Nie, BB; Qi, XY; Wang, YJ; Wu, FF; Li, XL; Bai, F; Chen, XC; Xu, L; Ren, QG; Zhang, ZJ; Nie BB(聂彬彬)
刊名ONCOTARGET
2016
卷号7期号:36页码:57556
关键词Alzheimer's disease 5XFAD mice cognition neuroimaging manganese enhanced MRI Pathology Section
DOI10.18632/oncotarget.11353
文章类型期刊论文
英文摘要Dysfunction of neuronal activity is a major and early contributor to cognitive impairment in Alzheimer's disease (AD). To investigate neuronal activity alterations at early stage of AD, we encompassed behavioral testing and in vivo manganese-enhanced magnetic resonance imaging (MEMRI) in 5XFAD mice at early ages (1-, 2-, 3-and 5-month). The 5XFAD model over-express human amyloid precursor protein (APP) and presenilin 1 (PS1) harboring five familial AD mutations, which have a high APP expression correlating with a high burden and an accelerated accumulation of the 42 amino acid species of amyloid-beta. In the Morris water maze, 5XFAD mice showed longer escape latency and poorer memory retention. In the MEMRI, 5XFAD mice showed increased signal intensity in the brain regions involved in spatial cognition, including the entorhinal cortex, the hippocampus, the retrosplenial cortex and the caudate putamen. Of note, the observed alterations in spatial cognition were associated with increased MEMRI signal intensity. These findings indicate that aberrant increased basal neuronal activity may contribute to the spatial cognitive function impairment at early stage of AD, and may further suggest the potential use of MEMRI to predict cognitive impairments. Early intervention that targets aberrant neuronal activity may be crucial to prevent cognitive impairment.
类目[WOS]Oncology ; Cell Biology
关键词[WOS]MILD COGNITIVE IMPAIRMENT ; FAMILIAL ALZHEIMERS-DISEASE ; IN-VIVO ; AMYLOID-BETA ; HIPPOCAMPAL HYPERACTIVITY ; RETROSPLENIAL CORTEX ; MUTANT MICE ; MODEL ; ACTIVATION ; MRI
WOS记录号WOS:000387153200008
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260524
专题中国科学院高能物理研究所_核技术应用研究中心_期刊论文
作者单位中国科学院高能物理研究所
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Tang, X,Wu, D,Gu, LH,et al. Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging[J]. ONCOTARGET,2016,7(36):57556.
APA Tang, X.,Wu, D.,Gu, LH.,Nie, BB.,Qi, XY.,...&聂彬彬.(2016).Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging.ONCOTARGET,7(36),57556.
MLA Tang, X,et al."Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging".ONCOTARGET 7.36(2016):57556.
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