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Synthesis and molecular structure of arene ruthenium(II) benzhydrazone complexes: impact of substitution at the chelating ligand and arene moiety on antiproliferative activity
Subarkhan, MKM; Ramesh, R; Liu Y(刘宇); Liu, Y
2016
发表期刊NEW JOURNAL OF CHEMISTRY
卷号40期号:11页码:9813-9823
文章类型期刊论文
摘要A convenient method for the synthesis of ruthenium(II) arene benzhydrazone complexes (1-6) of the general formula [(eta(6)-arene)Ru(L)Cl] (arene-benzene or p-cymene; L-monobasic bidentate substituted indole-3-carboxaldehye benzhydrazone derivatives) has been described. The complexes have been fully characterized via elemental analysis, IR, UV-vis, NMR and ESI-MS spectral methods. The solid-state molecular structures of the representative complexes were determined using a single-crystal X-ray diffraction study and the results indicated the presence of a pseudo octahedral (piano stool) geometry. All the complexes were thoroughly screened for their cytotoxicity against human cervical cancer cells (HeLa), human breast cancer cell line (MDA-MB-231) and human liver carcinoma cells (Hep G2) under in vitro conditions. Interestingly, the cytotoxic activity of complexes 3, 4 and 6 is much more potent than cis-platin with low IC50 values against all the cancer cell lines tested. Furthermore, the mode of cell death in the MDA-MB-231 cells was assessed via AO-EB staining, Hoechst 33258 staining, flow cytometry and comet assay. Furthermore, the results of Western blot analyses suggest that complexes 3 and 6 accumulate preferentially in the mitochondria of MDA-MB-231 cells and induce apoptosis via mitochondrial pathways by up-regulating p53 and Bax, and down-regulating Bcl-2.
DOI10.1039/C6NJ01936F
关键词[WOS]MITOCHONDRIA-MEDIATED APOPTOSIS ; HALF-SANDWICH COMPLEXES ; HUMAN CANCER-CELLS ; G-QUADRUPLEX DNA ; ANTICANCER ACTIVITY ; IN-VITRO ; HYDRAZONE COMPLEXES ; BINDING ; DERIVATIVES ; INHIBITION
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000387621500097
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260523
专题核技术应用研究中心
多学科研究中心
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Subarkhan, MKM,Ramesh, R,Liu Y,et al. Synthesis and molecular structure of arene ruthenium(II) benzhydrazone complexes: impact of substitution at the chelating ligand and arene moiety on antiproliferative activity[J]. NEW JOURNAL OF CHEMISTRY,2016,40(11):9813-9823.
APA Subarkhan, MKM,Ramesh, R,刘宇,&Liu, Y.(2016).Synthesis and molecular structure of arene ruthenium(II) benzhydrazone complexes: impact of substitution at the chelating ligand and arene moiety on antiproliferative activity.NEW JOURNAL OF CHEMISTRY,40(11),9813-9823.
MLA Subarkhan, MKM,et al."Synthesis and molecular structure of arene ruthenium(II) benzhydrazone complexes: impact of substitution at the chelating ligand and arene moiety on antiproliferative activity".NEW JOURNAL OF CHEMISTRY 40.11(2016):9813-9823.
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