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Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment
Hui, JJ; Xi, GJ; Liu, SS; Li, XL; Geng, LY; Teng, GJ; Nie, BB; Shan, BC; Yan, J; Dong, L; Reynold, GP; Zhang, ZJ; Nie BB(聂彬彬); Dan BC(单保慈)
2016
发表期刊BEHAVIOURAL BRAIN RESEARCH
卷号311页码:210
文章类型期刊论文
摘要Background: People exposed to stressful experience are at increased risk of the development of depression. A number of functional imaging studies have found disturbances in the mood-regulating circuit of the stress-exposed depressed patients, although few animal imaging studies have been undertaken addressing the brain functional changes of depression. Methods: Two rat models of depression: maternal separation (MS) and chronic unpredictable mild stress (CUMS), imitating early life stress and adult stress respectively, were administered with escitalopram. The differences in functional brain changes were determined by blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI). Results: Increased BOLD activation was observed in some brain regions of MS and CUMS animals, such as the bilateral hypothalamus, limbic system, hippocampus and frontal lobe, which were parts of mood regulating circuit. Furthermore, the MS- and CUMS-induced increases in BOLD activation were partially attenuated by chronic escitalopram treatment. Conclusions: These results suggested hyperactivation of mood-regulating circuit at baseline in the depressed animals exposed to stressful experience, and escitalopram can at least partially reverse these effects. (C) 2016 Elsevier B.V. All rights reserved.
关键词Depression Rat Magnetic resonance imaging Blood oxygen level-dependent Escitalopram
DOI10.1016/j.bbr.2016.05.044
关键词[WOS]FUNCTIONAL MAGNETIC-RESONANCE ; RAT-BRAIN ; ANTIDEPRESSANT TREATMENT ; STRESS ; CONNECTIVITY ; TEMPLATE ; MRI ; ACTIVATION ; PREFERENCE ; DISORDER
WOS类目Behavioral Sciences ; Neurosciences
WOS记录号WOS:000380418200023
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260518
专题核技术应用研究中心
作者单位中国科学院高能物理研究所
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Hui, JJ,Xi, GJ,Liu, SS,et al. Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment[J]. BEHAVIOURAL BRAIN RESEARCH,2016,311:210.
APA Hui, JJ.,Xi, GJ.,Liu, SS.,Li, XL.,Geng, LY.,...&单保慈.(2016).Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment.BEHAVIOURAL BRAIN RESEARCH,311,210.
MLA Hui, JJ,et al."Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment".BEHAVIOURAL BRAIN RESEARCH 311(2016):210.
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