Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment
Hui, JJ; Xi, GJ; Liu, SS; Li, XL; Geng, LY; Teng, GJ; Nie, BB; Shan, BC; Yan, J; Dong, L; Reynold, GP; Zhang, ZJ; Nie BB(聂彬彬); Dan BC(单保慈)
刊名BEHAVIOURAL BRAIN RESEARCH
2016
卷号311页码:210
关键词Depression Rat Magnetic resonance imaging Blood oxygen level-dependent Escitalopram
DOI10.1016/j.bbr.2016.05.044
文章类型期刊论文
英文摘要Background: People exposed to stressful experience are at increased risk of the development of depression. A number of functional imaging studies have found disturbances in the mood-regulating circuit of the stress-exposed depressed patients, although few animal imaging studies have been undertaken addressing the brain functional changes of depression. Methods: Two rat models of depression: maternal separation (MS) and chronic unpredictable mild stress (CUMS), imitating early life stress and adult stress respectively, were administered with escitalopram. The differences in functional brain changes were determined by blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI). Results: Increased BOLD activation was observed in some brain regions of MS and CUMS animals, such as the bilateral hypothalamus, limbic system, hippocampus and frontal lobe, which were parts of mood regulating circuit. Furthermore, the MS- and CUMS-induced increases in BOLD activation were partially attenuated by chronic escitalopram treatment. Conclusions: These results suggested hyperactivation of mood-regulating circuit at baseline in the depressed animals exposed to stressful experience, and escitalopram can at least partially reverse these effects. (C) 2016 Elsevier B.V. All rights reserved.
类目[WOS]Behavioral Sciences ; Neurosciences
关键词[WOS]FUNCTIONAL MAGNETIC-RESONANCE ; RAT-BRAIN ; ANTIDEPRESSANT TREATMENT ; STRESS ; CONNECTIVITY ; TEMPLATE ; MRI ; ACTIVATION ; PREFERENCE ; DISORDER
WOS记录号WOS:000380418200023
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260518
专题中国科学院高能物理研究所_核技术应用研究中心_期刊论文
作者单位中国科学院高能物理研究所
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Hui, JJ,Xi, GJ,Liu, SS,et al. Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment[J]. BEHAVIOURAL BRAIN RESEARCH,2016,311:210.
APA Hui, JJ.,Xi, GJ.,Liu, SS.,Li, XL.,Geng, LY.,...&单保慈.(2016).Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment.BEHAVIOURAL BRAIN RESEARCH,311,210.
MLA Hui, JJ,et al."Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment".BEHAVIOURAL BRAIN RESEARCH 311(2016):210.
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