IHEP OpenIR  > 核技术应用研究中心
Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients
Bai, Y; Wang, WX; Xu, J; Zhang, FR; Yu, HJ; Luo, CR; Wang, LZ; Chen, XY; Shan, BC; Xu, L; Xu, XF; Cheng, YQ; Dan BC(单保慈)
2016
Source PublicationPSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
EISSN1872-7506
Volume258Pages:37-43
SubtypeArticle
AbstractThis study aimed to explore the effects of the long-acting antipsychotic drug palmitate paliperidone in resting-state brain activity of schizophrenia patients. Seventeen schizophrenia outpatients were included and received palmitate paliperidone injection (PAL) treatment for 13 weeks. These patients were compared to seventeen matched healthy controls. All subjects underwent two scan sessions of resting-state magnetic resonance imaging (baseline and the 13th week) and regional homogeneity (ReHo) at resting-state where compared. After 13 weeks of treatment, PAL increased ReHo of the prefrontal cortex, anterior cingulate gyrus and orbital frontal gyrus, while PAL decreased ReHo of the thalamus, parahippocampal gyrus and superior temporal gyrus. Furthermore, improvement of psychiatric symptoms correlated with changing amplitude of ReHo: positively correlated with postcentral gyrus and negatively correlated with the occipital cortex. Baseline ReHo values of the middle occipital gyrus were positively correlated with the rate of reduction of psychiatric symptoms and improvement of social function. These results suggested that PAL might achieve its clinical effect in schizophrenia by influencing the resting-state function of the occipital cortex, lateral prefrontal cortex and temporal lobe. Baseline function of the inferior occipital gyrus might potentially predict the short-term effect of PAL in schizophrenia.
KeywordSchizophrenia Paliperidone palmitate Resting state fMRI ReHo Antipsychotics
DOI10.1016/j.pscychresns.2016.10.008
WOS KeywordAUDITORY VERBAL HALLUCINATIONS ; 1ST-EPISODE SCHIZOPHRENIA ; NAIVE PATIENTS ; DEFAULT-MODE ; FUNCTIONAL CONNECTIVITY ; CINGULATE CORTEX ; DEFICITS ; FMRI ; METAANALYSIS ; MEDICATION
Indexed BySCI
Language英语
WOS SubjectClinical Neurology ; Neuroimaging ; Psychiatry
WOS IDWOS:000389511600006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/260516
Collection核技术应用研究中心
Affiliation中国科学院高能物理研究所
Recommended Citation
GB/T 7714
Bai, Y,Wang, WX,Xu, J,et al. Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2016,258:37-43.
APA Bai, Y.,Wang, WX.,Xu, J.,Zhang, FR.,Yu, HJ.,...&单保慈.(2016).Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients.PSYCHIATRY RESEARCH-NEUROIMAGING,258,37-43.
MLA Bai, Y,et al."Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients".PSYCHIATRY RESEARCH-NEUROIMAGING 258(2016):37-43.
Files in This Item:
File Name/Size DocType Version Access License
20160904.pdf(664KB)期刊论文作者接受稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Bai, Y]'s Articles
[Wang, WX]'s Articles
[Xu, J]'s Articles
Baidu academic
Similar articles in Baidu academic
[Bai, Y]'s Articles
[Wang, WX]'s Articles
[Xu, J]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Bai, Y]'s Articles
[Wang, WX]'s Articles
[Xu, J]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.