Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients
Bai, Y; Wang, WX; Xu, J; Zhang, FR; Yu, HJ; Luo, CR; Wang, LZ; Chen, XY; Shan, BC; Xu, L; Xu, XF; Cheng, YQ; Dan BC(单保慈)
刊名PSYCHIATRY RESEARCH-NEUROIMAGING
2016
卷号258页码:37-43
关键词Schizophrenia Paliperidone palmitate Resting state fMRI ReHo Antipsychotics
DOI10.1016/j.pscychresns.2016.10.008
文章类型期刊论文
英文摘要This study aimed to explore the effects of the long-acting antipsychotic drug palmitate paliperidone in resting-state brain activity of schizophrenia patients. Seventeen schizophrenia outpatients were included and received palmitate paliperidone injection (PAL) treatment for 13 weeks. These patients were compared to seventeen matched healthy controls. All subjects underwent two scan sessions of resting-state magnetic resonance imaging (baseline and the 13th week) and regional homogeneity (ReHo) at resting-state where compared. After 13 weeks of treatment, PAL increased ReHo of the prefrontal cortex, anterior cingulate gyrus and orbital frontal gyrus, while PAL decreased ReHo of the thalamus, parahippocampal gyrus and superior temporal gyrus. Furthermore, improvement of psychiatric symptoms correlated with changing amplitude of ReHo: positively correlated with postcentral gyrus and negatively correlated with the occipital cortex. Baseline ReHo values of the middle occipital gyrus were positively correlated with the rate of reduction of psychiatric symptoms and improvement of social function. These results suggested that PAL might achieve its clinical effect in schizophrenia by influencing the resting-state function of the occipital cortex, lateral prefrontal cortex and temporal lobe. Baseline function of the inferior occipital gyrus might potentially predict the short-term effect of PAL in schizophrenia.
类目[WOS]Clinical Neurology ; Neuroimaging ; Psychiatry
关键词[WOS]AUDITORY VERBAL HALLUCINATIONS ; 1ST-EPISODE SCHIZOPHRENIA ; NAIVE PATIENTS ; DEFAULT-MODE ; FUNCTIONAL CONNECTIVITY ; CINGULATE CORTEX ; DEFICITS ; FMRI ; METAANALYSIS ; MEDICATION
WOS记录号WOS:000389511600006
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260516
专题中国科学院高能物理研究所_核技术应用研究中心_期刊论文
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Bai, Y,Wang, WX,Xu, J,et al. Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2016,258:37-43.
APA Bai, Y.,Wang, WX.,Xu, J.,Zhang, FR.,Yu, HJ.,...&单保慈.(2016).Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients.PSYCHIATRY RESEARCH-NEUROIMAGING,258,37-43.
MLA Bai, Y,et al."Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients".PSYCHIATRY RESEARCH-NEUROIMAGING 258(2016):37-43.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
20160904.pdf(664KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Bai, Y]的文章
[Wang, WX]的文章
[Xu, J]的文章
百度学术
百度学术中相似的文章
[Bai, Y]的文章
[Wang, WX]的文章
[Xu, J]的文章
必应学术
必应学术中相似的文章
[Bai, Y]的文章
[Wang, WX]的文章
[Xu, J]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 20160904.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。