DNA-Based Nanopore Sensing
Liu L(刘蕾); Wu HC(吴海臣); Liu, L; Wu, HC
刊名ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2016
卷号55期号:49页码:15216-15222
关键词current signatures DNA probes nanopores quantification sensing
DOI10.1002/anie.201604405
通讯作者吴海臣
文章类型期刊论文
英文摘要Nanopore sensing is an attractive, label-free approach that can measure single molecules. Although initially proposed for rapid and low-cost DNA sequencing, nanopore sensors have been successfully employed in the detection of a wide variety of substrates. Early successes were mostly achieved based on two main strategies by 1)creating sensing elements inside the nanopore through protein mutation and chemical modification or 2)using molecular adapters to enhance analyte recognition. Over the past fiveyears, DNA molecules started to be used as probes for sensing rather than substrates for sequencing. In this Minireview, we highlight the recent research efforts of nanopore sensing based on DNA-mediated characteristic current events. As nanopore sensing is becoming increasingly important in biochemical and biophysical studies, DNA-based sensing may find wider applications in investigating DNA-involving biological processes.
类目[WOS]Chemistry, Multidisciplinary
关键词[WOS]SOLID-STATE NANOPORES ; ACCURATE DATA PROCESS ; SINGLE-NUCLEOTIDE RESOLUTION ; ALPHA-HEMOLYSIN NANOPORE ; WALLED CARBON NANOTUBES ; HOST-GUEST INTERACTIONS ; PORE-FORMING PROTEIN ; DOUBLE-STRANDED DNA ; LABEL-FREE ; MOLECULAR ADAPTERS
语种英语
WOS记录号WOS:000389224000004
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260456
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Liu L,Wu HC,Liu, L,et al. DNA-Based Nanopore Sensing[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(49):15216-15222.
APA 刘蕾,吴海臣,Liu, L,&Wu, HC.(2016).DNA-Based Nanopore Sensing.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(49),15216-15222.
MLA 刘蕾,et al."DNA-Based Nanopore Sensing".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.49(2016):15216-15222.
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