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Elevated mercury bound to serum proteins in methylmercury poisoned rats after selenium treatment
Li YY(李云云); Li, YY; Fan, YQ; Li YY(李云云); Zhao JT(赵甲亭); Xu XH(徐小晗); Jing H(景晖); Gao YX(高愈希); Li B(李柏); Li YF(李玉锋); Zhao, JT; Xu, XH; Jing, H; Shang, LH; Gao, YX; Li, B; Li, YF
2016
发表期刊BIOMETALS
卷号29期号:5页码:893-903
通讯作者李玉锋
文章类型期刊论文
摘要Methylmercury is a toxic pollutant and is generated by microbial methylation of elemental or inorganic mercury in the environment. Previous study found decreased hepatic MDA levels and urinary mercury levels in methylmercury poisoned rats after sodium selenite treatment. This study further found increased mercury levels in serum samples from methylmercury poisoned rats after selenium treatment. By using size exclusion chromatography coupled to inductively coupled plasma mass spectrometry, three Hg- binding protein fractions and two Se-binding protein fractions were identified with the molecular weight of approximately 21, 40, and 75 kDa and of 40 and 75 kDa, respectively. Elevated mercury level in the 75 kDa protein fraction was found binding with both Hg and Se, which may explain the decreased urinary Hg excretion in MeHg poisoned rats after Se treatment. MALDI-TOF-MS analysis of the serum found that the 75 kDa protein fractions were albumin binding with both Hg and Se and the 21 kDa fraction was Hg- binding metallothionein.
关键词Methylmercury Selenite Albumin SEC-ICP-MS MALDI-TOF-MS Rats
DOI10.1007/s10534-016-9961-1
关键词[WOS]HG-SE COMPLEX ; INORGANIC MERCURY ; ORGANIC SELENIUM ; SELENOPROTEIN P ; TOXICITY ; EXPOSURE ; BINDING ; FISH ; MICE ; METALLOTHIONEIN
语种英语
WOS类目Biochemistry & Molecular Biology
WOS记录号WOS:000385252400012
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260449
专题多学科研究中心
实验物理中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Li YY,Li, YY,Fan, YQ,et al. Elevated mercury bound to serum proteins in methylmercury poisoned rats after selenium treatment[J]. BIOMETALS,2016,29(5):893-903.
APA 李云云.,Li, YY.,Fan, YQ.,李云云.,赵甲亭.,...&Li, YF.(2016).Elevated mercury bound to serum proteins in methylmercury poisoned rats after selenium treatment.BIOMETALS,29(5),893-903.
MLA 李云云,et al."Elevated mercury bound to serum proteins in methylmercury poisoned rats after selenium treatment".BIOMETALS 29.5(2016):893-903.
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