Folic acid-conjugated superparamagnetic iron oxide nanoparticles for tumor-targeting MR imaging
Li L(李雷); Li, L; Gao, FM; Jiang, WW; Wu, XL; Cai, YY; Tang, JT; Gao, XY; Gao, FP; Gao XY(高学云); Gao FP(高福平)
刊名DRUG DELIVERY
2016
卷号23期号:5页码:1726-1733
关键词Fe3O4 magnetic nanoparticles MR imaging poly(ethyleneimine) tumor targeting
DOI10.3109/10717544.2015.1006404
文章类型期刊论文
英文摘要Superparamagnetic iron oxide nanoparticles (SPIONs) have been the subject of extensive research due to their potential biomedical applications. In the present investigation, superparamagnetic FA-PEI-Fe3O4 were successfully prepared and evaluated as a targeted MRI contrast agent. FTIR characteristics, TGA, VSM, and MR imaging confirmed the composition and magnetic properties of the synthesized nanoparticles. TEM showed that FA-PEI-Fe3O4 were spherical in shape and well dispersed. The nanoparticles were superparamagnetic at room temperature with a saturation magnetization value of 67.1 emu/g. The nanoparticles showed higher uptake efficiency due to receptor-mediated endocytosis. Moreover, specificity of FA-PEI-Fe3O4 to target tumor cells was demonstrated by the increased nanoparticle uptake and significant contrast enhancement of KB cells over MCF7 cells. The competitive inhibition of FA-PEI-Fe3O4 by free FA further confirmed the specific interaction of this conjugate with FA receptors. In vivo MR imaging studies showed a decreased signal intensity and enhanced tumor contrast post-injection of FA-PEI-Fe3O4. These results indicate that FA-PEI-Fe3O4 can be used as a promising tumor-targeting agent as well as a T-2 negative-contrast agent in MR imaging applications.
类目[WOS]Pharmacology & Pharmacy
关键词[WOS]FOLATE RECEPTOR ; IN-VIVO ; MAGNETITE NANOPARTICLES ; DRUG-DELIVERY ; CELLS ; THERAPY ; CLUSTERS ; GLIOMA
语种英语
WOS记录号WOS:000382949300023
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260445
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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Li L,Li, L,Gao, FM,et al. Folic acid-conjugated superparamagnetic iron oxide nanoparticles for tumor-targeting MR imaging[J]. DRUG DELIVERY,2016,23(5):1726-1733.
APA 李雷.,Li, L.,Gao, FM.,Jiang, WW.,Wu, XL.,...&高福平.(2016).Folic acid-conjugated superparamagnetic iron oxide nanoparticles for tumor-targeting MR imaging.DRUG DELIVERY,23(5),1726-1733.
MLA 李雷,et al."Folic acid-conjugated superparamagnetic iron oxide nanoparticles for tumor-targeting MR imaging".DRUG DELIVERY 23.5(2016):1726-1733.
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