Investigating the stability of gold nanorods modified with thiol molecules for biosensing
Gong YX(宫永翔); Liu J(刘建); Liu RC(刘润聪); Wang JJ(王娇娇); Zhu WF(朱文凤); Li M(李敏); Zhao YL(赵宇亮); Gong, YX; Liu, J; Liu, RC; Wang, JJ; Niu, CM; Zhu, WF; Xu, DM; Hu, ZB; Li, M; Zhao, YL
刊名RSC ADVANCES
2016
卷号6期号:1页码:174-178
DOI10.1039/c5ra22133a
通讯作者李敏 ; 赵宇亮
文章类型期刊论文
英文摘要Gold nanorods (GNRs) modified with functional molecules are useful in chemical and biological sensing. In this work, the extinction spectrum of purified GNRs prepared by seed-mediated growth is systematically characterized by UV-visible absorption spectroscopy to test its stability before and after alkane-thiol modification. The results show that purification of GNRs makes the GNRs less stable, while a GNRs colloid solution functionalized by 11-mercaptoundecanoic acid (MUA), 3,30-dithiobis[6-nitrobenzoic acid] bis(succinimide) ester (DSNB), or 16-mercaptohexadecanoic acid (MHA), respectively is stable over time. Bovine serum albumin (BSA) as a sample protein can be successfully attached to DSNB modified GNRs and form stable BSA-DSNB-GNRs probes. The red-shift observed in the extinction spectrum due to the BSA attachment is consistent over repeated experiments. Finally, anti-PSA (prostate-specific antigen) as a capture antibody is also attached to DSNB-modified GNRs. The attached anti-PSA is capable of interacting with prostate-specific antigens and induces a further red-shift, suggesting potential applications of thiol modified GNRs in bio-sensing.
类目[WOS]Chemistry, Multidisciplinary
关键词[WOS]PLASMON RESONANCE SPECTROSCOPY ; ENHANCED RAMAN-SCATTERING ; NANOPARTICLES ; ABSORPTION ; THERAPY ; BIOCHIP
语种英语
WOS记录号WOS:000367250900022
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260438
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Gong YX,Liu J,Liu RC,et al. Investigating the stability of gold nanorods modified with thiol molecules for biosensing[J]. RSC ADVANCES,2016,6(1):174-178.
APA 宫永翔.,刘建.,刘润聪.,王娇娇.,朱文凤.,...&Zhao, YL.(2016).Investigating the stability of gold nanorods modified with thiol molecules for biosensing.RSC ADVANCES,6(1),174-178.
MLA 宫永翔,et al."Investigating the stability of gold nanorods modified with thiol molecules for biosensing".RSC ADVANCES 6.1(2016):174-178.
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