Mesoporous Bamboo Charcoal Nanoparticles as a New Near-Infrared Responsive Drug Carrier for Imaging-Guided Chemotherapy/Photothermal Synergistic Therapy of Tumor
Dong XH(董兴华); Yin WY(尹文艳); Yu J(余杰); Dong RX(董瑞霞); Bo T(薄涛); Zhang X(张潇); Yan L(晏亮); Yong Y(雍媛); Gu ZJ(谷战军); Zhao YL(赵宇亮); Dong, XH; Yin, WY; Yu, J; Dou, RX; Bao, T; Zhang, X; Yan, L; Yong, Y; Su, CJ; Wang, Q; Gu, ZJ; Zhao, YL
刊名ADVANCED HEALTHCARE MATERIALS
2016
卷号5期号:13页码:1627-1637
DOI10.1002/adhm.201600287
通讯作者谷战军 ; 赵宇亮
文章类型期刊论文
英文摘要Near-infrared-(NIR)-light-triggered photothermal nanocarriers have attracted much attention for the construction of more smart and effective therapeutic platforms in nanomedicine. Here, a multifunctional drug carrier based on a low cost, natural, and biocompatible material, bamboo charcoal nanoparticles (BCNPs), which are prepared by the pyrolysis of bamboo followed by physical grinding and ultrasonication is reported. The as-prepared BCNPs with porous structure possess not only large surface areas for drug loading but also an efficient photothermal effect, making them become both a suitable drug carrier and photothermal agent for cancer therapy. After loading doxorubicin (DOX) into the BCNPs, the resulting DOX-BCNPs enhance drug potency and more importantly can overcome the drug resistance of DOX in a MCF-7 cancer cell model by significantly increasing cellular uptake while remarkably decreasing drug efflux. The in vivo synergistic effect of combining chemotherapy and photothermal therapy in this drug delivery system is also demonstrated. In addition, the BCNPs enhance optoacoustic imaging contrast due to their high NIR absorbance. Collectively, it is demonstrated that the BCNP drug delivery system constitutes a promising and effective nanocarrier for simultaneous bioimaging and chemo-photothermal synergistic therapy of cancer.
类目[WOS]Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
关键词[WOS]CELLS IN-VITRO ; PHOTOTHERMAL THERAPY ; CANCER-THERAPY ; DELIVERY ; NANOMATERIALS ; GRAPHENE ; CARBON ; VIVO ; BIOMEDICINE ; NANOSHEETS
语种英语
WOS记录号WOS:000382763500011
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260434
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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Dong XH,Yin WY,Yu J,et al. Mesoporous Bamboo Charcoal Nanoparticles as a New Near-Infrared Responsive Drug Carrier for Imaging-Guided Chemotherapy/Photothermal Synergistic Therapy of Tumor[J]. ADVANCED HEALTHCARE MATERIALS,2016,5(13):1627-1637.
APA 董兴华.,尹文艳.,余杰.,董瑞霞.,薄涛.,...&Zhao, YL.(2016).Mesoporous Bamboo Charcoal Nanoparticles as a New Near-Infrared Responsive Drug Carrier for Imaging-Guided Chemotherapy/Photothermal Synergistic Therapy of Tumor.ADVANCED HEALTHCARE MATERIALS,5(13),1627-1637.
MLA 董兴华,et al."Mesoporous Bamboo Charcoal Nanoparticles as a New Near-Infrared Responsive Drug Carrier for Imaging-Guided Chemotherapy/Photothermal Synergistic Therapy of Tumor".ADVANCED HEALTHCARE MATERIALS 5.13(2016):1627-1637.
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