Multifunctional WS2@Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer
Zhang, CF; Yong Y(雍媛); Yong, Y; Song, L; Dong, XH; Zhang, X; Liu, XF; Gu, ZJ; Zhao, YL; Hu, ZB; Dong XH(董兴华); Zhang X(张潇); Gu ZJ(谷战军); Zhao YL(赵宇亮)
刊名ADVANCED HEALTHCARE MATERIALS
2016
卷号5期号:21页码:2776-2787
关键词gene therapy mild hyperthermia photoaccoustic imaging photothermal therapy synergistic therapy WS2@PEI nanoplatform X-ray computed tomography
DOI10.1002/adhm.201600633
通讯作者谷战军 ; 赵宇亮
文章类型期刊论文
英文摘要The combination of photothermal therapy (PTT) with gene therapy (GT) to improve PTT efficiency and thus eliminate cancer cells under mild hyperthermia is highly needed. Herein, multifunctional WS2@poly(ethylene imine) (WS2@PEI) nanoplatform has been designed and constructed for gene-photothermal synergistic therapy of tumors at mild condition. After a surface modification of WS2 with a positively charged PEI, the as-prepared WS2@PEI nanoplatform can not only act as an efficient survivin-siRNA carrier for GT but also exhibit remarkable near-infrared (NIR) photothermal effects for PTT. On the one hand, the photothermal effects induced by WS2@PEI upon NIR irradiation can enhance the cellular uptake owing to the increase of the cell membrane permeability, which leads to the remarkable enhancement of silencing efficiency of survivin. On the other hand, the silencing of survivin can increase the apoptosis as well as reduce the heat resistance of cancer cells by downregulating the heat shock protein 70 expressions, which greatly enhance the sensitivity of cancer cells to PTT. As a result, compared to PTT or GT treatment alone, WS2@PEI mediated synergistic GT/PTT therapy remarkably enhances in vitro cancer cell damage and in vivo tumor elimination.
类目[WOS]Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
关键词[WOS]SINGLE-LAYER MOS2 ; GOLD-NANORODS ; LASER IRRADIATION ; CARBON NANOTUBES ; DRUG-DELIVERY ; NANOPARTICLES ; NANOSHEETS ; TUMOR ; SIRNA ; CELLS
语种英语
WOS记录号WOS:000387662700007
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260417
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Zhang, CF,Yong Y,Yong, Y,et al. Multifunctional WS2@Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer[J]. ADVANCED HEALTHCARE MATERIALS,2016,5(21):2776-2787.
APA Zhang, CF.,雍媛.,Yong, Y.,Song, L.,Dong, XH.,...&赵宇亮.(2016).Multifunctional WS2@Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer.ADVANCED HEALTHCARE MATERIALS,5(21),2776-2787.
MLA Zhang, CF,et al."Multifunctional WS2@Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer".ADVANCED HEALTHCARE MATERIALS 5.21(2016):2776-2787.
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