Hesperetin Liposomes for Cancer Therapy
Wolfram, J; Scott, B; Boom, K; Shen, JL; Borsoi, C; Suri, K; Grande, R; Fresta, M; Celia, C; Zhao, YL; Shen, H; Ferrari, M; Zhao YL(赵宇亮)
刊名CURRENT DRUG DELIVERY
2016
卷号13期号:5页码:711-719
关键词Breast cancer Drug delivery Flavanone Lung cancer MDR-1 Natural products
DOI10.2174/1567201812666151027142412
文章类型期刊论文
英文摘要Hesperetin is a compound from citrus fruit that has previously been found to exert anticancer activity through a variety of mechanisms. However, the application of hesperetin to cancer therapy has been hampered by its hydrophobicity, necessitating the use of toxic solubilizing agents. Here, we have developed the first liposome-based delivery system for hesperetin. Liposomes were fabricated using the thin-layer evaporation technique and physical and pharmacological parameters were measured. The liposomes remained stable for prolonged periods of time in serum and under storage conditions, and displayed anticancer efficacy in both H441 lung cancer cells and MDA-MB-231 breast cancer cells. Furthermore, the anticancer activity was not impaired in cells expressing the multidrug resistance protein 1 (MDR-1). In conclusion, the encapsulation of hesperetin in liposomes does not interfere with therapeutic efficacy and provides a biocompatible alternative to toxic solubilizing agents, thereby enabling future clinical use of this compound for cancer therapy.
类目[WOS]Pharmacology & Pharmacy
关键词[WOS]COLON-CANCER ; MACROMOLECULAR THERAPEUTICS ; DRUG-DELIVERY ; IN-VITRO ; EFFICACY ; CELLS ; TOXICITY ; DIMETHYLSULFOXIDE ; POLYETHYLENIMINE ; NANOPARTICLES
语种英语
WOS记录号WOS:000384800000008
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260404
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
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GB/T 7714
Wolfram, J,Scott, B,Boom, K,et al. Hesperetin Liposomes for Cancer Therapy[J]. CURRENT DRUG DELIVERY,2016,13(5):711-719.
APA Wolfram, J.,Scott, B.,Boom, K.,Shen, JL.,Borsoi, C.,...&赵宇亮.(2016).Hesperetin Liposomes for Cancer Therapy.CURRENT DRUG DELIVERY,13(5),711-719.
MLA Wolfram, J,et al."Hesperetin Liposomes for Cancer Therapy".CURRENT DRUG DELIVERY 13.5(2016):711-719.
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