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A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells
Scott, B; Shen, JL; Nizzero, S; Boom, K; Persano, S; Mi, Y; Liu, XW; Zhao, YL; Blanco, E; Shen, HF; Ferrari, M; Wolfram, J; Zhao YL(赵宇亮)
2016
发表期刊PHARMACOLOGICAL RESEARCH
卷号111页码:413-421
文章类型期刊论文
摘要Cancer cells have high rates of glycolysis and lactic acid fermentation in order to fuel accelerated rates of cell division (Warburg effect). Here, we present a strategy for merging cancer and yeast metabolism to remove pyruvate, a key intermediate of cancer cell metabolism, and produce the toxic compound acetaldehyde. This approach was achieved by administering the yeast enzyme pyruvate decarboxylase to triple negative breast cancer cells. To overcome the challenges of protein delivery, a nanoparticle-based system consisting of cationic lipids and porous silicon were employed to obtain efficient intracellular uptake. The results demonstrate that the enzyme therapy decreases cancer cell viability through production of acetaldehyde and reduction of lactic acid fermentation. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Cancer metabolism Multistage vector Nanotechnology Pyruvate decarboxylase Warburg effect
DOI10.1016/j.phrs.2016.07.005
关键词[WOS]NEGATIVE BREAST-CANCER ; MULTISTAGE VECTOR DELIVERY ; IN-VIVO ; PHOTOTHERMAL THERAPY ; SILICON PARTICLES ; LUNG METASTASIS ; SIRNA ; NANOPARTICLES ; ACETALDEHYDE ; DEGRADATION
语种英语
WOS类目Pharmacology & Pharmacy
WOS记录号WOS:000384784000040
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文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260396
专题多学科研究中心
作者单位中国科学院高能物理研究所
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Scott, B,Shen, JL,Nizzero, S,et al. A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells[J]. PHARMACOLOGICAL RESEARCH,2016,111:413-421.
APA Scott, B.,Shen, JL.,Nizzero, S.,Boom, K.,Persano, S.,...&赵宇亮.(2016).A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells.PHARMACOLOGICAL RESEARCH,111,413-421.
MLA Scott, B,et al."A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells".PHARMACOLOGICAL RESEARCH 111(2016):413-421.
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