Metabolic Characteristics of 16HBE and A549 Cells Exposed to Different Surface Modified Gold Nanorods
Liu, ZG; Wang LM(王黎明); Wang, LM; Zhang, LM; Wu, XC; Nie, GJ; Chen, CY; Tang, HR; Wang, YL; Wu XC(吴晓春); Nie GJ(聂广军); Chen CY(陈春英)
刊名ADVANCED HEALTHCARE MATERIALS
2016
卷号5期号:18页码:2363-2375
DOI10.1002/adhm.201600164
文章类型期刊论文
英文摘要Gold nanorods (AuNRs) have shown their great potential in cancer treatment due to their special physiochemical and optical properties, and the ease of surface modification. However, the molecular mechanism of biological effects induced by different surface modified AuNRs remains largely undetermined. Herein, this study for the first time systematically analyzed metabolic impacts of three surface modified AuNRs in cancer and noncancer cells detected by NMR and GC-FID/MS metabolomics and validated by molecular biological approach. It is found that positively and negatively charged AuNRs induce different metabolic consequences. Most importantly, it is found that the PEI-AuNRs display specific cytotoxicity to A549 cells while posing little impact on 16HBE cells. The cytotoxicity of PEI-AuNRs to A549 cells is manifested in large disruptions to the cell metabolisms, which affects energy metabolism, choline metabolism, the hexosamine biosynthesis pathway, and oxidative stress to cells. The results of this study provide comprehensive molecular information on the distinct biological effects of different surface modified AuNRs, and can be valuable in designing purpose-driven nanomaterials. Most importantly, this work highlights the potential of metabolomics coupled with molecular biological techniques in screening antitumor nanodrugs and revealing the molecular mechanism of their biological effects.
类目[WOS]Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
关键词[WOS]CELLULAR UPTAKE ; LUNG-CANCER ; TUMOR-CELLS ; NANOPARTICLES ; CHEMISTRY ; CYTOTOXICITY ; GLYCOSYLATION ; SPECTROSCOPY ; MECHANISMS ; TOXICITY
语种英语
WOS记录号WOS:000384554300008
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260391
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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Liu, ZG,Wang LM,Wang, LM,et al. Metabolic Characteristics of 16HBE and A549 Cells Exposed to Different Surface Modified Gold Nanorods[J]. ADVANCED HEALTHCARE MATERIALS,2016,5(18):2363-2375.
APA Liu, ZG.,王黎明.,Wang, LM.,Zhang, LM.,Wu, XC.,...&陈春英.(2016).Metabolic Characteristics of 16HBE and A549 Cells Exposed to Different Surface Modified Gold Nanorods.ADVANCED HEALTHCARE MATERIALS,5(18),2363-2375.
MLA Liu, ZG,et al."Metabolic Characteristics of 16HBE and A549 Cells Exposed to Different Surface Modified Gold Nanorods".ADVANCED HEALTHCARE MATERIALS 5.18(2016):2363-2375.
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