Identification of a Novel Parallel beta-Strand Conformation within Molecular Monolayer of Amyloid Peptide
Liu, L; Li, Q; Zhang, S; Wang, XF; Hoffmann, SV; Li, JY; Liu, Z; Besenbacher, F; Dong, MD; Wang XF(王晓峰); Li JY(李敬源)
刊名ADVANCED SCIENCE
2016
卷号3期号:6
DOI10.1002/advs.201500369
文章类型期刊论文
英文摘要The differentiation of protein properties and biological functions arises from the variation in the primary and secondary structure. Specifically, in abnormal assemblies of protein, such as amyloid peptide, the secondary structure is closely correlated with the stable ensemble and the cytotoxicity. In this work, the early A beta(33-42) aggregates forming the molecular monolayer at hydrophobic interface are investigated. The molecular monolayer of amyloid peptide A beta(33-42) consisting of novel parallel beta-strand-like structure is further revealed by means of a quantitative nanomechanical spectroscopy technique with force controlled in pico-Newton range, combining with molecular dynamic simulation. The identified parallel beta-strand-like structure of molecular monolayer is distinct from the antiparallel beta-strand structure of A beta(33-42) amyloid fibril. This finding enriches the molecular structures of amyloid peptide aggregation, which could be closely related to the pathogenesis of amyloid disease.
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
关键词[WOS]ALZHEIMERS-DISEASE ; FORCE MICROSCOPY ; FIBRIL FORMATION ; PROTEIN ; OLIGOMERS ; SPECTROSCOPY ; MECHANISM ; BEAMLINES ; TOXICITY ; MODEL
语种英语
WOS记录号WOS:000379934800005
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260390
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Liu, L,Li, Q,Zhang, S,et al. Identification of a Novel Parallel beta-Strand Conformation within Molecular Monolayer of Amyloid Peptide[J]. ADVANCED SCIENCE,2016,3(6).
APA Liu, L.,Li, Q.,Zhang, S.,Wang, XF.,Hoffmann, SV.,...&李敬源.(2016).Identification of a Novel Parallel beta-Strand Conformation within Molecular Monolayer of Amyloid Peptide.ADVANCED SCIENCE,3(6).
MLA Liu, L,et al."Identification of a Novel Parallel beta-Strand Conformation within Molecular Monolayer of Amyloid Peptide".ADVANCED SCIENCE 3.6(2016).
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