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A Copper(II) Complex Based on N-(4-hydroxybenzyl)-L-serine: Synthesis, Crystal Structure and Inhibitory Activity on PTP1B and TCPTP
Li, YH; Lu, LP; Zhu, ML; Yuan, CX; Feng, SS; Gao, ZQ; Gao ZQ(高增强)
2016
发表期刊CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
卷号35期号:11页码:1686-1693
摘要A novel copper(II) complex with the reduced Schiff base, [Cu(L)(2)]center dot H2O (I, HL = N-(4-hydroxybenzyl)-L-serine), was prepared in aqueous solution and characterized by elemental analysis, FT-IR, electrospray ionization mass spectrometry and single-crystal X-ray diffraction. Complex I crystallizes in the orthorhombic system, space group P2(1)2(1)2(1), with a = 8.9040(18), b = 9.1530(18), c = 24.891(5) angstrom, V = 2028.6(7) angstrom(3), Z = 4, C20H26CuN2O9, M-r = 501.97, D-c = 1.644g.cm(3), mu = 1.135 mm(-1), F(000) = 1044, GOOF = 1.194, the final R = 0.0484 and wR = 0.1420 for 6186 observed reflections (I > 2 sigma(I)). In I, two L- anions are coordinated to the copper ion in tridentate and bidentate chelating modes, respectively, resulting in the coordinated geometry of copper ion to be a distorted square pyramid. The intermolecular hydrogen bonds between the complexes, complexes and lattice water molecules lead to a 2D supramolecular network. The bioactivity of the complex as a potential PTPs inhibitory agent in vitro was investigated, displaying potent inhibition against PTP1B (IC50, 0.27 mu M) and TCPTP (IC50, 0.57 mu M) with a moderate selectivity.
文章类型期刊论文
关键词copper(II) complex N-(4-hydroxybenzyl)-L-serine crystal structure inhibitor PTP1B TCPTP
DOI10.14102/j.cnki.0254-5861.2011-1213
关键词[WOS]PROTEIN-TYROSINE PHOSPHATASES ; SCHIFF-BASE ; POTENT INHIBITION ; CU(II) COMPLEXES ; DNA INTERACTION ; LIGANDS
语种英语
WOS类目Chemistry, Inorganic & Nuclear ; Crystallography
WOS记录号WOS:000393097900007
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260385
专题多学科研究中心
作者单位中国科学院高能物理研究所
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Li, YH,Lu, LP,Zhu, ML,et al. A Copper(II) Complex Based on N-(4-hydroxybenzyl)-L-serine: Synthesis, Crystal Structure and Inhibitory Activity on PTP1B and TCPTP[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,2016,35(11):1686-1693.
APA Li, YH.,Lu, LP.,Zhu, ML.,Yuan, CX.,Feng, SS.,...&高增强.(2016).A Copper(II) Complex Based on N-(4-hydroxybenzyl)-L-serine: Synthesis, Crystal Structure and Inhibitory Activity on PTP1B and TCPTP.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,35(11),1686-1693.
MLA Li, YH,et al."A Copper(II) Complex Based on N-(4-hydroxybenzyl)-L-serine: Synthesis, Crystal Structure and Inhibitory Activity on PTP1B and TCPTP".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 35.11(2016):1686-1693.
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