Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-drug Interactions
Gao, LQ; Chen J(陈俊); Hu Y(胡毅); Chen, J; Hu, Y; Sun, HY; Ong, YS; Zhang, JX; Chai, ZF; Lee, SS
刊名CURRENT ORGANIC CHEMISTRY
2016
卷号20期号:17页码:1827-1834
关键词Bupropion drug-drug interactions (DDIs) gemfibrozil metabolites pharmacodynamics pharmacokinetics
DOI10.2174/1385272820666151102212542
通讯作者胡毅
文章类型期刊论文
英文摘要The potential of metabolites to contribute to drug-drug interactions (DDIs) has not been well defined so far. However, metabolites of parent drug compounds can contribute to both side effects and DDIs. To address this unmet challenge, we introduce recent advances as well as our perspectives of the metabolites in DDIs in this review. Firstly, we review several typical examples of organic small molecule drug metabolites as major contributors to DDIs in clinic. Since some of the metabolites are so important in the contributions to DDIs, we then further review how to identify active metabolites in vivo and when such metabolites should trigger DDI assessment. Lastly, we review in vivo animal models, especially humanized/chimeric mice, in improving the quality of preclinical DDI assessments.
类目[WOS]Chemistry, Organic
关键词[WOS]MESSENGER-RNA EXPRESSION ; HUMAN CYTOCHROMES P450 ; PREGNANE-X RECEPTOR ; TYROSINEMIA TYPE-I ; HUMANIZED LIVER ; CHIMERIC MICE ; CLINICAL PHARMACOKINETICS ; TRICYCLIC ANTIDEPRESSANTS ; PLASMA-CONCENTRATIONS ; HEPATIC-DYSFUNCTION
语种英语
WOS记录号WOS:000380833700008
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260380
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Gao, LQ,Chen J,Hu Y,et al. Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-drug Interactions[J]. CURRENT ORGANIC CHEMISTRY,2016,20(17):1827-1834.
APA Gao, LQ.,陈俊.,胡毅.,Chen, J.,Hu, Y.,...&Lee, SS.(2016).Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-drug Interactions.CURRENT ORGANIC CHEMISTRY,20(17),1827-1834.
MLA Gao, LQ,et al."Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-drug Interactions".CURRENT ORGANIC CHEMISTRY 20.17(2016):1827-1834.
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