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Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications
Yin WY(尹文艳); Yu J(于杰); Yan L(晏亮); Zheng LR(郑黎荣); Gu ZJ(谷战军); Zhao YL(赵宇亮); Yin, WY; Yu, J; Lv, FT; Yan, L; Zheng, LR; Gu, ZJ; Zhao, YL
2016
Source PublicationACS NANO
ISSN1936-0851
EISSN1936-086X
Volume10Issue:12Pages:11000-11011
Corresponding Author尹文艳 ; 谷战军 ; 赵宇亮
SubtypeArticle
AbstractWe have developed a biocompatible antibacterial system based on polyethylene glycol functionalized molybdenum disulfide nanoflowers (PEG-MoS2 NFs). The PEG-MoS2 NFs have high near-infrared (NIR) absorption and peroxidase-like activity, which can efficiently catalyze decomposition of low concentration of H2O2 to generate hydroxyl radicals (center dot OH). The conversion of H2O2 into center dot OH can avoid the toxicity of high concentration of H2O2 and the center dot OH has higher antibacterial activity, making resistant bacteria more vulnerable and wounds more easily cured. The PEG-MoS2 NFs combine the catalysis with MR photothermal effect, providing a rapid and effective killing outcome in vitro for Gram-negative ampicillin resistant Escherichia coli (Amp(r) E. coli) and Gram-positive endospore-forming Bacillus subtilis (B. subtilis) as compared to catalytic treatment or photothermal therapy (PTT) alone. Wound healing results indicate that the synergy antibacterial system could be conveniently used for wound disinfection in vivo. Interestingly, glutathione (GSH) oxidation can be accelerated due to the 808 mu irradiation induced hyperthermia at the presence of PEG-MoS2 NFs proved by X-ray near-edge absorption spectra and X-ray spectroscopy. The accelerated GSH oxidation can result in bacterial death more easily. A mechanism based on center dot OH-enhanced PTT is proposed to explain the antibacterial process.
KeywordMoS2 peroxidase-like activity wound disinfection photothermal therapy
DOI10.1021/acsnano.6b05810
WOS KeywordGRAPHENE QUANTUM DOTS ; ESCHERICHIA-COLI ; MOS2 NANOSHEETS ; HYDROGEN-PEROXIDE ; FERROMAGNETIC NANOPARTICLES ; COLORIMETRIC DETECTION ; RESISTANT BACTERIA ; 2-DIMENSIONAL MOS2 ; BIOFILM FORMATION ; DNA-DAMAGE
Indexed BySCI
Language英语
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000391079700044
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/260372
Collection多学科研究中心
Affiliation中国科学院高能物理研究所
Recommended Citation
GB/T 7714
Yin WY,Yu J,Yan L,et al. Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications[J]. ACS NANO,2016,10(12):11000-11011.
APA 尹文艳.,于杰.,晏亮.,郑黎荣.,谷战军.,...&Zhao, YL.(2016).Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications.ACS NANO,10(12),11000-11011.
MLA 尹文艳,et al."Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications".ACS NANO 10.12(2016):11000-11011.
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