IHEP OpenIR  > 多学科研究中心
Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications
Yin WY(尹文艳); Yu J(于杰); Yan L(晏亮); Zheng LR(郑黎荣); Gu ZJ(谷战军); Zhao YL(赵宇亮); Yin, WY; Yu, J; Lv, FT; Yan, L; Zheng, LR; Gu, ZJ; Zhao, YL
2016
发表期刊ACS NANO
卷号10期号:12页码:11000-11011
通讯作者尹文艳 ; 谷战军 ; 赵宇亮
摘要We have developed a biocompatible antibacterial system based on polyethylene glycol functionalized molybdenum disulfide nanoflowers (PEG-MoS2 NFs). The PEG-MoS2 NFs have high near-infrared (NIR) absorption and peroxidase-like activity, which can efficiently catalyze decomposition of low concentration of H2O2 to generate hydroxyl radicals (center dot OH). The conversion of H2O2 into center dot OH can avoid the toxicity of high concentration of H2O2 and the center dot OH has higher antibacterial activity, making resistant bacteria more vulnerable and wounds more easily cured. The PEG-MoS2 NFs combine the catalysis with MR photothermal effect, providing a rapid and effective killing outcome in vitro for Gram-negative ampicillin resistant Escherichia coli (Amp(r) E. coli) and Gram-positive endospore-forming Bacillus subtilis (B. subtilis) as compared to catalytic treatment or photothermal therapy (PTT) alone. Wound healing results indicate that the synergy antibacterial system could be conveniently used for wound disinfection in vivo. Interestingly, glutathione (GSH) oxidation can be accelerated due to the 808 mu irradiation induced hyperthermia at the presence of PEG-MoS2 NFs proved by X-ray near-edge absorption spectra and X-ray spectroscopy. The accelerated GSH oxidation can result in bacterial death more easily. A mechanism based on center dot OH-enhanced PTT is proposed to explain the antibacterial process.
文章类型期刊论文
关键词MoS2 peroxidase-like activity wound disinfection photothermal therapy
DOI10.1021/acsnano.6b05810
关键词[WOS]GRAPHENE QUANTUM DOTS ; ESCHERICHIA-COLI ; MOS2 NANOSHEETS ; HYDROGEN-PEROXIDE ; FERROMAGNETIC NANOPARTICLES ; COLORIMETRIC DETECTION ; RESISTANT BACTERIA ; 2-DIMENSIONAL MOS2 ; BIOFILM FORMATION ; DNA-DAMAGE
语种英语
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000391079700044
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260372
专题多学科研究中心
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Yin WY,Yu J,Yan L,et al. Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications[J]. ACS NANO,2016,10(12):11000-11011.
APA 尹文艳.,于杰.,晏亮.,郑黎荣.,谷战军.,...&Zhao, YL.(2016).Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications.ACS NANO,10(12),11000-11011.
MLA 尹文艳,et al."Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications".ACS NANO 10.12(2016):11000-11011.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
20161183.pdf(2433KB)期刊论文作者接受稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[尹文艳]的文章
[于杰]的文章
[晏亮]的文章
百度学术
百度学术中相似的文章
[尹文艳]的文章
[于杰]的文章
[晏亮]的文章
必应学术
必应学术中相似的文章
[尹文艳]的文章
[于杰]的文章
[晏亮]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。