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The reactive activities of natural amino acids: key principles of peptide-templated Au cluster synthesis
Li X(李旭); Li N(李楠); Zhao LN(赵丽娜); Li, X; Li, N; Zhao, LN
2016
发表期刊SCIENCE BULLETIN
卷号61期号:22页码:1732-1738
通讯作者赵丽娜
摘要Coating of gold nanoclusters with peptides is an important targeting method in biomedical applications. However, their synthetic method highly influences their targeting ability. Current methods often use harsh reagents and organic solvents to control morphology, which are not preferred for biomedical applications. Recently, several peptides with specific amino acid sequences have successfully been used to reduce Au ions and synthesize biocompatible peptide-covered gold particles in situ. However, the molecular mechanism of peptide-assisted nanocluster formation is yet unclear. Thus, reactive abilities of different amino acids should be studied to improve design of peptides with predetermined amino acid content and consequently, synthesize gold nanoclusters with improved performance. In this theoretical study, we have approximated the reactive abilities of 20 natural amino acids in their neutral state using density functional theory calculations, such as Fukui indices and HOMO/LUMO composition analysis. We have found that the top reducing agents are tryptophan, histidine, and tyrosine, and the strongest binding can be expected from methionine and cysteine. Further study of the exact reactive sites in these high reactive amino acids provided the deep insight for the peptide design route for the targeted gold nanocluster formation.
文章类型期刊论文
关键词Reactive activity Amino acid Synthesis in situ Au nanocluster DFT calculation
DOI10.1007/s11434-016-1195-7
关键词[WOS]FLUORESCENT GOLD NANOCLUSTERS ; DIRECTED SYNTHESIS ; ALPHA(IIB)BETA(3) INTEGRIN ; SENSITIVE DETECTION ; CELL ; DESIGN
语种英语
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000388645200007
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260369
专题多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Li X,Li N,Zhao LN,et al. The reactive activities of natural amino acids: key principles of peptide-templated Au cluster synthesis[J]. SCIENCE BULLETIN,2016,61(22):1732-1738.
APA 李旭,李楠,赵丽娜,Li, X,Li, N,&Zhao, LN.(2016).The reactive activities of natural amino acids: key principles of peptide-templated Au cluster synthesis.SCIENCE BULLETIN,61(22),1732-1738.
MLA 李旭,et al."The reactive activities of natural amino acids: key principles of peptide-templated Au cluster synthesis".SCIENCE BULLETIN 61.22(2016):1732-1738.
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