Synthesis, Crystal Structure and Protein Tyrosine Phosphatase Inhibition of a Copper(II) Complex with N-(2-Pyridylmethyl)-L-serine
Li, YH; Yuan, CX; Lu, LP; Zhu, ML; Fu, XQ; Xing, S; Gao, ZQ; Gao ZQ(高增强)
刊名CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
2016
卷号37期号:12页码:2138-2143
关键词Copper(II) complex N-(2-Pyridylmethyl)-L-serine Inhibitor PTP1B TCPTP
DOI10.7503/cjcu20160563
其他题名N-(2-吡啶甲基)-L-丝氨酸铜配合物的合成、晶体结构及抑制蛋白酪氨酸磷酸酶活性
通讯作者高增强
文章类型期刊论文
英文摘要The reaction of the reduced Schiff base HL [N-(2-pyridylmethyl)-L-serine] with CuCl2 center dot 2H(2)O in molar ratio of 1 : 1 in methanol solution afforded a new neutral mononuclear complex [CuLCl(H2O)] (I). The structure was determined by single. crystal X-ray diffraction and further characterized by elemental analysis, FTIR, electrospray ionization mass spectrometry and powder X-ray diffraction. In complex., the Cu(II) ion adopts five. coordinated mode in a square pyramidal configuration which is completed by one oxygen and two nitrogen atoms from the L- anion, one chloride anion and one water molecule. The discrete copper coordination units were extended into a 2D supramolecular network through the intermolecular interactions. The bioactivity of the compound as a potential PTPs(Protein Tyrosine Phosphatases) inhibitory agent in vitro was investigated, displaying potent inhibition against PTP1B(IC50 = 0.32 mu mol/L) and TCPTP(IC50 = 0.45 mu mol/L).
类目[WOS]Chemistry, Multidisciplinary
关键词[WOS]SCHIFF-BASE ; COORDINATION POLYMERS ; OXOVANADIUM(IV) COMPLEXES ; POTENT INHIBITION ; CU(II) COMPLEXES ; DERIVATIVES ; LIGAND ; PTP1B ; BINDING ; ACIDS
语种中文
WOS记录号WOS:000389192700003
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260357
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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Li, YH,Yuan, CX,Lu, LP,et al. Synthesis, Crystal Structure and Protein Tyrosine Phosphatase Inhibition of a Copper(II) Complex with N-(2-Pyridylmethyl)-L-serine[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2016,37(12):2138-2143.
APA Li, YH.,Yuan, CX.,Lu, LP.,Zhu, ML.,Fu, XQ.,...&高增强.(2016).Synthesis, Crystal Structure and Protein Tyrosine Phosphatase Inhibition of a Copper(II) Complex with N-(2-Pyridylmethyl)-L-serine.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,37(12),2138-2143.
MLA Li, YH,et al."Synthesis, Crystal Structure and Protein Tyrosine Phosphatase Inhibition of a Copper(II) Complex with N-(2-Pyridylmethyl)-L-serine".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 37.12(2016):2138-2143.
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