Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage
Ge, CC; Fang, G; Shen, XM; Chong, Y; Wamer, WG; Gao, XF; Chai, ZF; Chen, CY; Yin, JJ; Chen CY(陈春英)
刊名ACS NANO
2016
卷号10期号:11页码:10436-10445
关键词palladium nanocrystals surface facet enzyme-like activity antioxidants computational chemistry oxidative stress
DOI10.1021/acsnano.6b06297
通讯作者陈春英
文章类型期刊论文
英文摘要To develop nanomaterials as artificial enzymes, it is necessary to better understand how their physicochemical properties affect their enzyme-like activities. Although prior research has demonstrated that nanomaterials exhibit tunable enzyme-like activities depending on their size, structure, and composition, few studies have examined the effect of surface facets, which determine surface energy or surface reactivity. Here, we use electron spin-resonance spectroscopy to report that lower surface energy {111}-faceted Pd octahedrons have greater intrinsic antioxidant enzyme like activity than higher surface energy {100}-faceted Pd nanocubes. Our in vitro experiments found that those same Pd octahedrons are more effective than Pd nanocubes at scavenging reactive oxygen species (ROS). Those reductions in ROS preserve the homogeneity of mitochondrial membrane potential and attenuate damage to important biomolecules, thereby allowing a substantially higher number of cells to survive oxidative challenges. Our computations of molecular mechanisms for the antioxidant activities of {111}- and {100}-faceted Pd nanocrystals, as well as their activity order, agree well with experimental observations. These findings can guide the design of antioxidant-mimicking nanomaterials, which could have therapeutic or preventative potential against oxidative stress related diseases.
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
关键词[WOS]METAL-ORGANIC FRAMEWORKS ; PEROXIDASE-LIKE ACTIVITY ; AUGMENTED-WAVE METHOD ; REACTIVE OXYGEN ; CATALYTIC-ACTIVITY ; ARTIFICIAL ENZYMES ; DNA-DAMAGE ; GLUTATHIONE-PEROXIDASE ; OXIDE NANOPARTICLES ; MOLECULAR-OXYGEN
语种英语
WOS记录号WOS:000388913100075
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260356
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
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Ge, CC,Fang, G,Shen, XM,et al. Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage[J]. ACS NANO,2016,10(11):10436-10445.
APA Ge, CC.,Fang, G.,Shen, XM.,Chong, Y.,Wamer, WG.,...&陈春英.(2016).Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage.ACS NANO,10(11),10436-10445.
MLA Ge, CC,et al."Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage".ACS NANO 10.11(2016):10436-10445.
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