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C-60(OH)(22): a potential histone deacetylase inhibitor with anti-angiogenic activity
Sun, CD; Wang LM(王黎明); Wang, LM; Gao, D; Pan, YM; Zhao, YL; Chen, CY; Guo, MZ; Pan YM(潘元明); Zhao YL(赵宇亮); Chen CY(陈春英)
2016
发表期刊NANOSCALE
卷号8期号:36页码:16332-16339
通讯作者陈春英
摘要C-60(OH)(22) has been reported to suppress human cancer by inhibiting angiogenesis. However, its mechanism of action remains unclear. To explore the role and mechanism of C-60(OH)(22) in human pancreatic cancer, siRNA knockdown, immunofluorescence and a matrigel plug mouse model were employed. The results demonstrated that C-60(OH)(22) suppresses endothelial cell invasion and tube formation in vitro. C-60(OH)(22) suppresses angiogenesis in human umbilical vein endothelial cell (HUVEC) xenograft mice. The enzymatic activities of MMP2 and MMP9, as well as the expression levels of HDAC1, HDAC2, HIF-1 alpha and VEGF, were inhibited by C-60(OH)(22). The expression of RECK was up-regulated by C-60(OH)(22) in HUVECs. The expression levels of HIF-1 alpha and VEGF were down-regulated and the expression of RECK was up-regulated after the knockdown of HDAC1 and HDAC2 in HUVECs. Cell invasion, tube formation, and the enzymatic activities of MMP2 and MMP9 were suppressed after the knockdown of HDAC1 or HDAC2 in HUVECs.
文章类型期刊论文
DOI10.1039/c6nr04875g
关键词[WOS]TUMOR ANGIOGENESIS ; CANCER ; RECK ; FULLERENOL ; INVASION ; CELLS ; MMP-2 ; C-60
语种英语
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000384531600026
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文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260314
专题多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Sun, CD,Wang LM,Wang, LM,et al. C-60(OH)(22): a potential histone deacetylase inhibitor with anti-angiogenic activity[J]. NANOSCALE,2016,8(36):16332-16339.
APA Sun, CD.,王黎明.,Wang, LM.,Gao, D.,Pan, YM.,...&陈春英.(2016).C-60(OH)(22): a potential histone deacetylase inhibitor with anti-angiogenic activity.NANOSCALE,8(36),16332-16339.
MLA Sun, CD,et al."C-60(OH)(22): a potential histone deacetylase inhibitor with anti-angiogenic activity".NANOSCALE 8.36(2016):16332-16339.
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