IHEP OpenIR  > 多学科研究中心
Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer
Yong Y(雍媛); Zhou LJ(周亮君); Yan L(晏亮); Gu ZJ(谷战军); Zhao YL(赵宇亮); Yong, Y; Zhou, LJ; Zhang, SS; Yan, L; Gu, ZJ; Zhang, GJ; Zhao, YL
2016
发表期刊NPG ASIA MATERIALS
卷号8
通讯作者谷战军 ; 赵宇亮
文章类型期刊论文
摘要The development of a new generation of nanoscaled theranostics with simple compositions and versatile properties to realize enhanced diagnoses and treatment outcomes and to avoid side effects is highly desirable but remains a great challenge. Here we report a new ultrasmall theranostic based on bovine serum albumin-coated GdW10O36 nanoclusters (GdW10NCs) as multifunctional theranostics for multifunctional bio-imaging, highly effective in vitro photothermal ablation of cancer cells and in vivo radiotherapy of tumors. The as-synthesized GdW10 NCs afford significantly enhanced computed tomography/magnetic resonance imaging signals and remarkable photothermal therapy (PTT)/radiotherapy therapy (RT) therapeutic effects for tumor treatment. Moreover, toxicity studies confirmed their low toxicity and efficient renal clearance, suggesting their potential for practical applications. These results indicated that the as-prepared GdW10 nanoclusters are promising as multifunctional nanotheranostics for multimodal imaging-guided PTT/RT of tumors. These results also encourage the further exploration of other polyoxometalate-based multifunctional nanotheranostics for cancer diagnoses and therapy.
DOI10.1038/am.2016.63
关键词[WOS]MRI CONTRAST AGENTS ; APOPTOTIC CELL-DEATH ; BOVINE SERUM-ALBUMIN ; DRUG-DELIVERY ; IN-VITRO ; SYNERGISTIC THERAPY ; GRAPHENE ANALOGS ; POLYOXOMETALATE ; NANOPARTICLES ; COMPLEXES
语种英语
WOS类目Materials Science, Multidisciplinary
WOS记录号WOS:000379759400006
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260308
专题多学科研究中心
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Yong Y,Zhou LJ,Yan L,et al. Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer[J]. NPG ASIA MATERIALS,2016,8.
APA 雍媛.,周亮君.,晏亮.,谷战军.,赵宇亮.,...&Zhao, YL.(2016).Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer.NPG ASIA MATERIALS,8.
MLA 雍媛,et al."Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer".NPG ASIA MATERIALS 8(2016).
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
20160520.pdf(4018KB)期刊论文作者接受稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[雍媛]的文章
[周亮君]的文章
[晏亮]的文章
百度学术
百度学术中相似的文章
[雍媛]的文章
[周亮君]的文章
[晏亮]的文章
必应学术
必应学术中相似的文章
[雍媛]的文章
[周亮君]的文章
[晏亮]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。