|One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer|
|Bo T(薄涛); Yin WY(尹文艳); Zheng XP(郑晓鹏); Zhang X(张潇); Yu J(余杰); Dong XH(董兴华); Yong Y(雍媛); Bao, T; Yin, WY; Zheng, XP; Zhang, X; Yu, J; Dong, XH; Yong, Y; Gao, FP; Yan, L; Gu, ZJ; Zhao, YL
|摘要||Engineering design of plasmonic nanomaterials as on-demand theranostic nanoagents with imaging, drug carrier, and photothermal therapy (FIT) functions have profound impact on treatment of cancer. Here, a facile 'one-pot' template-free hydrothermal route was firstly developed for synthesis of plasmonic oxygen deficiency molybdenum oxide hollow nanospheres functionalized by poly(ethylene glycol) (PEG-MoO3-x HNSs). The as-prepared PEG-MoO3-x HNSs not only have good biocompatibility but also exhibit obvious localized surface plasmon resonance (LSPR) absorption in the near-infrared (NIR) region. Especially, due to its intrinsic mesoporous properties and effective photothermal conversion efficiency upon 808-nm NIR laser irradiation, the PEG-MoO3-x HNSs can be applied as a pH/NIR laser dual-responsive camptothecin (CPT) drug delivery nanoplatform for chemotherapy as well as PTT to cancer cells. A remarkably improved synergistic therapeutic effect to pancreatic (PANC-1) tumor-bearing mice was obtained compared to the result of chemotherapy or PTT alone. Apart from its application for drug delivery, the PEG-MoO3-x HNSs can also be employed as an effective contrast nanoagent for photoacoustic (PAT) imaging because of its high NIR absorption, making it promising as a theranostic nanoagent for PAT imaging-guided chemo-photothermal combinational cancer therapy in the nanomedicine field. (c) 2015 Elsevier Ltd. All rights reserved.|
|关键词[WOS]||WALLED CARBON NANOTUBES
; ANTICANCER DRUG-DELIVERY
; BIOMEDICAL APPLICATIONS
; MOLYBDENUM TRIOXIDE
; THERANOSTIC PROBE
; Materials Science, Biomaterials
Bo T,Yin WY,Zheng XP,et al. One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer[J]. BIOMATERIALS,2016,76:11-24.
薄涛.,尹文艳.,郑晓鹏.,张潇.,余杰.,...&Zhao, YL.(2016).One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer.BIOMATERIALS,76,11-24.
薄涛,et al."One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer".BIOMATERIALS 76(2016):11-24.