|Polyhydroxylated fullerenols regulate macrophage for cancer adoptive immunotherapy and greatly inhibit the tumor metastasis|
|Tang JL(唐敬龙); Chen ZY(陈志云); Sun BY(孙宝云); Dong JQ(董金泉); Liu J(刘晶); Zhou HG(周慧鸽); Wang LM(王黎明); Bai R(白茹); Miao Q(苗青); Zhao YL(赵宇亮); Chen CY(陈春英); Liu Y(刘颖); Tang, JL; Chen, ZY; Sun, BY; Dong, JQ; Liu, J; Zhou, HG; Wang, LM; Bai, R; Miao, Q; Zhao, YL; Chen, CY; Liu, Y
|发表期刊||NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
|摘要||Adoptive immunotherapy is a highly effective approach for cancer treatment. Several potential adoptive immunotherapies have high (though reversible) toxicities with disappointing results. Polyhydroxylated fullerenols have been demonstrated as promising antitumor drugs with low toxicities. In this study, we investigate whether polyhydroxylated fullerenols (C-60(OH)(22) and Gd@C-82(OH)(22)) contribute to cancer immunotherapy by regulating macrophages. Our results show that fullerenols treatment enhances mitochondrial metabolism, phagocytosis and cytokine secretion. Moreover, activated macrophages inhibit the growth of several cancer cell types. It is likely that this inhibition is dependent on an NF-kappa B-mediated release of multiple cytokines. Using a lung metastasis model, we also show that autologous macrophages greatly suppress cancer cell metastasis to lung when they are activated by C-60(OH)(22) and Gd@C-82(OH)(22). More importantly, Gd@C-82(OH)(22) are shown to have stronger ability than C-60(OH)(22) to improve the macrophage function, which shed light on the rational design for nanomedicine and clinical application. From the Clinical Editor: The interest in the use of immunotherapy in cancer has rekindled recently. However, many approaches have shown disappointing results. In this study, the authors investigated the effects of polyhydroxylated fullerenol nanoparticles on regulating macrophages for immunotherapy. These positive findings may point a novel way to cancer treatment. (C) 2015 Elsevier Inc. All rights reserved.|
|WOS类目||Nanoscience & Nanotechnology
; Medicine, Research & Experimental
Tang JL,Chen ZY,Sun BY,et al. Polyhydroxylated fullerenols regulate macrophage for cancer adoptive immunotherapy and greatly inhibit the tumor metastasis[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2016,12(4):945-954.
唐敬龙.,陈志云.,孙宝云.,董金泉.,刘晶.,...&Liu, Y.(2016).Polyhydroxylated fullerenols regulate macrophage for cancer adoptive immunotherapy and greatly inhibit the tumor metastasis.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,12(4),945-954.
唐敬龙,et al."Polyhydroxylated fullerenols regulate macrophage for cancer adoptive immunotherapy and greatly inhibit the tumor metastasis".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 12.4(2016):945-954.