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The polyvinylpyrrolidone functionalized rGO/Bi2S3 nanocomposite as a near-infrared light-responsive nanovehicle for chemo-photothermal therapy of cancer
Dou RX(豆瑞霞); Du Z(杜祯); Bao T(鲍涛); Dong XH(董兴华); Zheng XP(郑晓鹏); Yu M(俞淼); Yin WY(尹文艳); Yan L(晏亮); Gu ZJ(谷战军); Dou, RX; Du, Z; Bao, T; Dong, XH; Zheng, XP; Yu, M; Yin, WY; Dong, BB; Yan, L; Gu, ZJ
2016
发表期刊NANOSCALE
卷号8期号:22页码:11531-11542
通讯作者晏亮 ; 谷战军
文章类型期刊论文
摘要Recently, a combination of chemotherapy with photothermal therapy (PTT) has received great attention for the construction of a near infrared (NIR)-controlled drug-delivery system for synergistic treatment of cancer, ultimately resulting in the enhancement of the therapeutic efficacy of anticancer drugs. Here, we developed a novel system for synergistic cancer therapy based on bismuth sulfide (Bi2S3) nanoparticle-decorated graphene functionalized with polyvinylpyrrolidone (PVP) (named PVP-rGO/Bi2S3). The as-prepared PVP-rGO/Bi2S3 nanocomposite has a high storage capacity for anticancer drugs (similar to 500% for doxorubicin (DOX)) and simultaneously has perfect photothermal conversion efficiency in the NIR region. The results of the in vitro accumulative drug release test manifests that the PVP-rGO/Bi2S3 nanocomposite could be applied as a dual pH-and NIR-responsive nanotherapeutic carrier for the controlled release of DOX from DOX-loaded PVP-rGO/Bi2S3 (PVP-rGO/Bi2S3@DOX). Moreover, the treatment of both cancer cells (including Hela, MCF-7, HepG2 and BEL-7402 cells) and BEL-7402 tumor-bearing mice with the PVP-rGO/Bi2S3@DOX complex followed by NIR laser irradiation produces significantly greater inhibition of cancer cell growth than the treatment with NIR irradiation alone or DOX alone, exhibiting a synergistic antitumor effect. Furthermore, due to the obvious NIR and X-ray absorption ability, the PVP-rGO/Bi2S3 nanocomposite could be employed as a dual-modal contrast agent for both photoacoustic tomography and X-ray computed tomography imaging. In addition to the good biocompatibility, the PVP-rGO/Bi2S3 nanocomposite paves a potential way for the fabrication of theranostic agents for dual-modal imaging-guided chemo-photothermal combined cancer therapy.
DOI10.1039/c6nr01543c
关键词[WOS]BISMUTH SULFIDE NANORODS ; REDUCED GRAPHENE OXIDE ; HUMAN-SERUM-ALBUMIN ; DRUG-DELIVERY ; RAMAN-SPECTROSCOPY ; NANOPARTICLES ; NANOSHEETS ; AGENT ; TUMOR ; WATER
语种英语
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000377919800026
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260296
专题多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Dou RX,Du Z,Bao T,et al. The polyvinylpyrrolidone functionalized rGO/Bi2S3 nanocomposite as a near-infrared light-responsive nanovehicle for chemo-photothermal therapy of cancer[J]. NANOSCALE,2016,8(22):11531-11542.
APA 豆瑞霞.,杜祯.,鲍涛.,董兴华.,郑晓鹏.,...&Gu, ZJ.(2016).The polyvinylpyrrolidone functionalized rGO/Bi2S3 nanocomposite as a near-infrared light-responsive nanovehicle for chemo-photothermal therapy of cancer.NANOSCALE,8(22),11531-11542.
MLA 豆瑞霞,et al."The polyvinylpyrrolidone functionalized rGO/Bi2S3 nanocomposite as a near-infrared light-responsive nanovehicle for chemo-photothermal therapy of cancer".NANOSCALE 8.22(2016):11531-11542.
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