|The polyvinylpyrrolidone functionalized rGO/Bi2S3 nanocomposite as a near-infrared light-responsive nanovehicle for chemo-photothermal therapy of cancer|
|Dou RX(豆瑞霞); Du Z(杜祯); Bao T(鲍涛); Dong XH(董兴华); Zheng XP(郑晓鹏); Yu M(俞淼); Yin WY(尹文艳); Yan L(晏亮); Gu ZJ(谷战军); Dou, RX; Du, Z; Bao, T; Dong, XH; Zheng, XP; Yu, M; Yin, WY; Dong, BB; Yan, L; Gu, ZJ
|摘要||Recently, a combination of chemotherapy with photothermal therapy (PTT) has received great attention for the construction of a near infrared (NIR)-controlled drug-delivery system for synergistic treatment of cancer, ultimately resulting in the enhancement of the therapeutic efficacy of anticancer drugs. Here, we developed a novel system for synergistic cancer therapy based on bismuth sulfide (Bi2S3) nanoparticle-decorated graphene functionalized with polyvinylpyrrolidone (PVP) (named PVP-rGO/Bi2S3). The as-prepared PVP-rGO/Bi2S3 nanocomposite has a high storage capacity for anticancer drugs (similar to 500% for doxorubicin (DOX)) and simultaneously has perfect photothermal conversion efficiency in the NIR region. The results of the in vitro accumulative drug release test manifests that the PVP-rGO/Bi2S3 nanocomposite could be applied as a dual pH-and NIR-responsive nanotherapeutic carrier for the controlled release of DOX from DOX-loaded PVP-rGO/Bi2S3 (PVP-rGO/Bi2S3@DOX). Moreover, the treatment of both cancer cells (including Hela, MCF-7, HepG2 and BEL-7402 cells) and BEL-7402 tumor-bearing mice with the PVP-rGO/Bi2S3@DOX complex followed by NIR laser irradiation produces significantly greater inhibition of cancer cell growth than the treatment with NIR irradiation alone or DOX alone, exhibiting a synergistic antitumor effect. Furthermore, due to the obvious NIR and X-ray absorption ability, the PVP-rGO/Bi2S3 nanocomposite could be employed as a dual-modal contrast agent for both photoacoustic tomography and X-ray computed tomography imaging. In addition to the good biocompatibility, the PVP-rGO/Bi2S3 nanocomposite paves a potential way for the fabrication of theranostic agents for dual-modal imaging-guided chemo-photothermal combined cancer therapy.|
|关键词[WOS]||BISMUTH SULFIDE NANORODS
; REDUCED GRAPHENE OXIDE
; Nanoscience & Nanotechnology
; Materials Science, Multidisciplinary
; Physics, Applied
Dou RX,Du Z,Bao T,et al. The polyvinylpyrrolidone functionalized rGO/Bi2S3 nanocomposite as a near-infrared light-responsive nanovehicle for chemo-photothermal therapy of cancer[J]. NANOSCALE,2016,8(22):11531-11542.
豆瑞霞.,杜祯.,鲍涛.,董兴华.,郑晓鹏.,...&Gu, ZJ.(2016).The polyvinylpyrrolidone functionalized rGO/Bi2S3 nanocomposite as a near-infrared light-responsive nanovehicle for chemo-photothermal therapy of cancer.NANOSCALE,8(22),11531-11542.
豆瑞霞,et al."The polyvinylpyrrolidone functionalized rGO/Bi2S3 nanocomposite as a near-infrared light-responsive nanovehicle for chemo-photothermal therapy of cancer".NANOSCALE 8.22(2016):11531-11542.