| Investigation of the fine structure around the copper site in copper/zinc superoxide dismutase by XANES combined with ab initio calculations | |
Wang, Yu1; Jin, Sheng2; Li, Jiong1; Zhou, Jing3; Zhang, Linjuan3; Wang, Jianqiang1,3; Zhang, Shuo1; Wei, Xiangjun1; Jiang, Zheng1; Huang, Yuying1; Cui, Peixin4; Zhao, Haifeng5 ; Chu, Wangsheng4,5; Zhao HF(赵海峰); Chu WS(储旺盛)
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| 2016 | |
| Source Publication | RADIATION PHYSICS AND CHEMISTRY
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| ISSN | 0969-806X |
| Pages | 88-92 |
| Subtype | Article; Proceedings Paper |
| Abstract | Copper/zinc superoxide dismutase (CuZnSOD) is an important enzyme that plays a crucial role in protecting oxygen-metabolizing cells against harmful effects of superoxide free-radicals. In this work, the three-dimensional local structure around the copper-binding site in pH 7.0 buffer solution was determined using X-ray absorption near-edge spectroscopy (XANES) combined with ab initio calculations in the framework of the multiple-scattering theory performed by MXAN. Extremely accurate bond distances and bond angle information between ligands were returned. The result confirmed that the copper ion binds four conserved His residues and a water molecule in CuZnSOD and prefers a five-coordinated in a distorted square pyramidal geometry. (C) 2016 Elsevier Ltd. All rights reserved. |
| Conference Title | 13th International Symposium on Radiation Physics (ISRP) |
| Conference Place | Univ Sci & Technol China, Beijing, PEOPLES R CHINA |
| Conference Date | SEP 07-11, 2015 |
| Keyword | Copper/zinc superoxide dismutase BioXAS Metalloprotein MXAN |
| DOI | 10.1016/j.radphyschem.2016.03.003 |
| Indexed By | SCI ; ADS |
| Language | 英语 |
| WOS ID | WOS:000404201800018 |
| ADS Bibcode | 2017RaPC..137...88W |
| ADS URL | https://ui.adsabs.harvard.edu/abs/2017RaPC..137...88W |
| ADS CITATIONS | https://ui.adsabs.harvard.edu/abs/2017RaPC..137...88W/citations |
| Citation statistics |
Cited Times:0 [ADS]
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| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/260287 |
| Collection | 多学科研究中心 |
| Affiliation | 1.中国科学院上海应用物理研究所上海同步辐射装置光源 2.河北医科大学 3.中国科学院上海应用物理研究所中国科学院微观界面物理与探测重点实验室 4.中国科学技术大学国家同步辐射实验室 5.中国科学院高能物理研究所 |
| Recommended Citation GB/T 7714 | Wang, Yu,Jin, Sheng,Li, Jiong,et al. Investigation of the fine structure around the copper site in copper/zinc superoxide dismutase by XANES combined with ab initio calculations[J]. RADIATION PHYSICS AND CHEMISTRY,2016:88-92. |
| APA | Wang, Yu.,Jin, Sheng.,Li, Jiong.,Zhou, Jing.,Zhang, Linjuan.,...&储旺盛.(2016).Investigation of the fine structure around the copper site in copper/zinc superoxide dismutase by XANES combined with ab initio calculations.RADIATION PHYSICS AND CHEMISTRY,88-92. |
| MLA | Wang, Yu,et al."Investigation of the fine structure around the copper site in copper/zinc superoxide dismutase by XANES combined with ab initio calculations".RADIATION PHYSICS AND CHEMISTRY (2016):88-92. |
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