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Investigation of the fine structure around the copper site in copper/zinc superoxide dismutase by XANES combined with ab initio calculations
Wang, Yu1; Jin, Sheng2; Li, Jiong1; Zhou, Jing3; Zhang, Linjuan3; Wang, Jianqiang1,3; Zhang, Shuo1; Wei, Xiangjun1; Jiang, Zheng1; Huang, Yuying1; Cui, Peixin4; Zhao, Haifeng5; Chu, Wangsheng4,5; Zhao HF(赵海峰); Chu WS(储旺盛)
2016
Source PublicationRADIATION PHYSICS AND CHEMISTRY
ISSN0969-806X
Pages88-92
SubtypeArticle; Proceedings Paper
AbstractCopper/zinc superoxide dismutase (CuZnSOD) is an important enzyme that plays a crucial role in protecting oxygen-metabolizing cells against harmful effects of superoxide free-radicals. In this work, the three-dimensional local structure around the copper-binding site in pH 7.0 buffer solution was determined using X-ray absorption near-edge spectroscopy (XANES) combined with ab initio calculations in the framework of the multiple-scattering theory performed by MXAN. Extremely accurate bond distances and bond angle information between ligands were returned. The result confirmed that the copper ion binds four conserved His residues and a water molecule in CuZnSOD and prefers a five-coordinated in a distorted square pyramidal geometry. (C) 2016 Elsevier Ltd. All rights reserved.
Conference Title13th International Symposium on Radiation Physics (ISRP)
Conference PlaceUniv Sci & Technol China, Beijing, PEOPLES R CHINA
Conference DateSEP 07-11, 2015
KeywordCopper/zinc superoxide dismutase BioXAS Metalloprotein MXAN
DOI10.1016/j.radphyschem.2016.03.003
Indexed BySCI ; ADS
Language英语
WOS IDWOS:000404201800018
ADS Bibcode2017RaPC..137...88W
ADS URLhttps://ui.adsabs.harvard.edu/abs/2017RaPC..137...88W
ADS CITATIONShttps://ui.adsabs.harvard.edu/abs/2017RaPC..137...88W/citations
Citation statistics
Cited Times:0 [ADS]
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/260287
Collection多学科研究中心
Affiliation1.中国科学院上海应用物理研究所上海同步辐射装置光源
2.河北医科大学
3.中国科学院上海应用物理研究所中国科学院微观界面物理与探测重点实验室
4.中国科学技术大学国家同步辐射实验室
5.中国科学院高能物理研究所
Recommended Citation
GB/T 7714
Wang, Yu,Jin, Sheng,Li, Jiong,et al. Investigation of the fine structure around the copper site in copper/zinc superoxide dismutase by XANES combined with ab initio calculations[J]. RADIATION PHYSICS AND CHEMISTRY,2016:88-92.
APA Wang, Yu.,Jin, Sheng.,Li, Jiong.,Zhou, Jing.,Zhang, Linjuan.,...&储旺盛.(2016).Investigation of the fine structure around the copper site in copper/zinc superoxide dismutase by XANES combined with ab initio calculations.RADIATION PHYSICS AND CHEMISTRY,88-92.
MLA Wang, Yu,et al."Investigation of the fine structure around the copper site in copper/zinc superoxide dismutase by XANES combined with ab initio calculations".RADIATION PHYSICS AND CHEMISTRY (2016):88-92.
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