|Rapid Degradation and High Renal Clearance of Cu3BiS3 Nanodots for Efficient Cancer Diagnosis and Photothermal Therapy in Vivo|
|Liu J(刘晶); Wang PY(王鹏阳); Zhao X(赵晓); Wang LM(王黎明); Wang DL(王东亮); Gu ZJ(谷战军); Tang JL(唐敬龙); Guo MY(郭梦雨); Cao MJ(曹明晶); Zhou HG(周慧鸽); Liu Y(刘颖); Chen CY(陈春英); Liu, J; Wang, PY; Zhang, X; Wang, LM; Wang, DL; Gu, ZJ; Tang, JL; Guo, MY; Cao, MJ; Zhou, HG; Liu, Y; Chen, CY
|摘要||A key challenge for the use of inorganic nanomedicines in clinical applications is their long-term accumulation in internal organs, which raises the common concern of the risk of adverse effects and inflammatory responses. It is thus necessary to rationally design inorganic nanomaterials with proper accumulation and clearance mechanism in vivo. Herein, we prepared ultrasmall Cu3BiS3 nanodots (NDs) as a single-phased ternary bimetal sulfide for photothermal cancer therapy guided by multispectral optoacoustic tomography (MSOT) and X-ray computed tomography (CT) due to bismuth's excellent X-ray attenuation coefficient. We then monitored and investigated their absorption, distribution, metabolism, and excretion. We also used CT imaging to demonstrate that Cu3BiS3 NDs can be quickly removed through renal clearance, which may be related to their small size, rapid chemical transformation, and degradation in an acidic lysosomal environment as characterized by synchrotron radiation-based X-ray absorption near-edge structure spectroscopy. These results reveal that Cu3BiS3 NDs act as a simple but powerful "theranostic" nanoplatform for MSOT/CT imaging guided tumor ablation with excellent metabolism and rapid clearance that will improve safety for clinical applications in the future.|
multispectral optoacoustic tomography
X-ray computed tomography
|关键词[WOS]||COPPER SULFIDE NANOPARTICLES
; CT CONTRAST AGENTS
; GOLD NANORODS
; QUANTUM DOTS
; II WINDOW
; Chemistry, Physical
; Nanoscience & Nanotechnology
; Materials Science, Multidisciplinary
Liu J,Wang PY,Zhao X,et al. Rapid Degradation and High Renal Clearance of Cu3BiS3 Nanodots for Efficient Cancer Diagnosis and Photothermal Therapy in Vivo[J]. ACS NANO,2016,10(4):4587-4598.
刘晶.,王鹏阳.,赵晓.,王黎明.,王东亮.,...&Chen, CY.(2016).Rapid Degradation and High Renal Clearance of Cu3BiS3 Nanodots for Efficient Cancer Diagnosis and Photothermal Therapy in Vivo.ACS NANO,10(4),4587-4598.
刘晶,et al."Rapid Degradation and High Renal Clearance of Cu3BiS3 Nanodots for Efficient Cancer Diagnosis and Photothermal Therapy in Vivo".ACS NANO 10.4(2016):4587-4598.