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Revealing different aggregational states of a conjugated polymer in solution by a nanopore sensor
Guo BY(郭秉元); Yao ZY(姚志轶); Liu L(刘蕾); Wu HC(吴海臣); Guo, BY; Yao, ZY; Liu, L; Wu, HC
2016
发表期刊CHEMICAL SCIENCE
卷号7期号:8页码:5287-5293
通讯作者吴海臣
文章类型期刊论文
摘要The functionalities of conjugated polymers are determined not only by local molecular structure, but also by the mesoscale conformational and morphological states of the polymer chains. Simulation studies have successfully established the connections between molecular structure and conformational states of certain conjugated polymers. However, experimental tools that can accurately discriminate between different conformational and morphological states of conjugated polymers are still scarce. Here, we use a nanopore sensor to analyze different aggregational states of a polythiophene derivative by threading the polymer through the pore under applied potentials. When the fluorescence of the polythiophene is quenched by pH tuning or the presence of Dy3+, the UV-vis and fluorescence spectra of the two solutions appear indistinguishable. However, threading the polymer molecules of these two solutions through an alpha-hemolysin nanopore affords entirely different translocation profiles owing to their different aggregational states. We further substantiate the results by conducting aggregational interconversion experiments and TEM measurements. This work has clearly indicated that nanopores are promising tools for the analysis of aggregational changes of conjugated polymers and may open new avenues for the investigation of aggregational states of biomacromolecules in the context of early disease diagnosis and prognosis.
DOI10.1039/c6sc00296j
关键词[WOS]ALPHA-HEMOLYSIN NANOPORES ; FIELD-EFFECT TRANSISTORS ; HOST-GUEST INTERACTIONS ; CHEMICAL SENSORS ; DNA ; POLYTHIOPHENES ; CHARGE ; MICRORNAS
语种英语
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000380893900060
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260262
专题多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Guo BY,Yao ZY,Liu L,et al. Revealing different aggregational states of a conjugated polymer in solution by a nanopore sensor[J]. CHEMICAL SCIENCE,2016,7(8):5287-5293.
APA 郭秉元.,姚志轶.,刘蕾.,吴海臣.,Guo, BY.,...&Wu, HC.(2016).Revealing different aggregational states of a conjugated polymer in solution by a nanopore sensor.CHEMICAL SCIENCE,7(8),5287-5293.
MLA 郭秉元,et al."Revealing different aggregational states of a conjugated polymer in solution by a nanopore sensor".CHEMICAL SCIENCE 7.8(2016):5287-5293.
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