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Folate-Conjugated Magnetic Nanoparticles for Tumor Hyperthermia Therapy: In Vitro and In Vivo Studies
Zheng, WP; Rong, Z; Gao FP(高福平); Gao XY(高学云); Gao J(高靓); Gao, FP; Cai, YY; Zhou, J; Chen, XY; Li, QQ; Gao, XY; Gao, L; Tang, JT
2016
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号16期号:8页码:8352-8359
文章类型期刊论文
摘要Magnetic hyperthermia using ferrite nanoparticles has emerged as a eutherapeutic approach for cancer treatment. In this study, we had constructed folate conjugated poly(ethyleneimine) (PEI) modified magnetic nanoparticles (FA-PEI-MNPs) that generate heat in an alternating magnetic field (AMF). Transmission electron microscope (TEM) showed that FA-PEI-MNPs were nearly spherical in shape. The mean diameter of these nanoparticles determined by DLS was 30.7 +/- 7.7 nm. The cytotoxicity assay showed that FA-PEI-MNPs exhibited no significant cytotoxicity against L929 cells. FA-PEI-MNPs have good hyperthermia effect on KB cells in vitro by magnetic field induced hyperthermia, especially at 45 degrees C and 47 degrees C. In in vivo hyperthermia treatment using FA-PEI-MNPs in a subcutaneous tumor xenograft model of KB cells tumor, the tumor temperature increased to 48 degrees C whereas the body temperature remained at around 37.5 degrees C. Thermotherapy with FA-PEI-MNPs led up to prolongation of survival over magnetic field controls, 66.7% (4/6) of subcutaneous tumors regressed completely. Histological examinations after treatment revealed large necrotic areas close to particle deposits. These results suggest that hyperthermia using FA-PEI-MNPs is an effective and specific therapy for tumor. This therapy may provide an alternative way to treat recurrent cancer refractory to other modalities.
关键词Hyperthermia Magnetic Nanoparticles Folate KB Cells Tumor
DOI10.1166/jnn.2016.12622
关键词[WOS]IRON-OXIDE NANOPARTICLES ; FOCUSED ULTRASOUND ABLATION ; TARGETED DRUG-DELIVERY ; ISSUE-ON REVIEWS ; BREAST-CANCER ; FOLIC-ACID ; BIOMEDICAL APPLICATIONS ; CATIONIC LIPOSOMES ; PROSTATE-CANCER ; NANOMATERIALS
语种英语
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000387083900083
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260247
专题多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Zheng, WP,Rong, Z,Gao FP,et al. Folate-Conjugated Magnetic Nanoparticles for Tumor Hyperthermia Therapy: In Vitro and In Vivo Studies[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(8):8352-8359.
APA Zheng, WP.,Rong, Z.,高福平.,高学云.,高靓.,...&Tang, JT.(2016).Folate-Conjugated Magnetic Nanoparticles for Tumor Hyperthermia Therapy: In Vitro and In Vivo Studies.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(8),8352-8359.
MLA Zheng, WP,et al."Folate-Conjugated Magnetic Nanoparticles for Tumor Hyperthermia Therapy: In Vitro and In Vivo Studies".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.8(2016):8352-8359.
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