Folate-Conjugated Magnetic Nanoparticles for Tumor Hyperthermia Therapy: In Vitro and In Vivo Studies
Zheng, WP; Rong, Z; Gao FP(高福平); Gao XY(高学云); Gao J(高靓); Gao, FP; Cai, YY; Zhou, J; Chen, XY; Li, QQ; Gao, XY; Gao, L; Tang, JT
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
2016
卷号16期号:8页码:8352-8359
关键词Hyperthermia Magnetic Nanoparticles Folate KB Cells Tumor
DOI10.1166/jnn.2016.12622
文章类型期刊论文
英文摘要Magnetic hyperthermia using ferrite nanoparticles has emerged as a eutherapeutic approach for cancer treatment. In this study, we had constructed folate conjugated poly(ethyleneimine) (PEI) modified magnetic nanoparticles (FA-PEI-MNPs) that generate heat in an alternating magnetic field (AMF). Transmission electron microscope (TEM) showed that FA-PEI-MNPs were nearly spherical in shape. The mean diameter of these nanoparticles determined by DLS was 30.7 +/- 7.7 nm. The cytotoxicity assay showed that FA-PEI-MNPs exhibited no significant cytotoxicity against L929 cells. FA-PEI-MNPs have good hyperthermia effect on KB cells in vitro by magnetic field induced hyperthermia, especially at 45 degrees C and 47 degrees C. In in vivo hyperthermia treatment using FA-PEI-MNPs in a subcutaneous tumor xenograft model of KB cells tumor, the tumor temperature increased to 48 degrees C whereas the body temperature remained at around 37.5 degrees C. Thermotherapy with FA-PEI-MNPs led up to prolongation of survival over magnetic field controls, 66.7% (4/6) of subcutaneous tumors regressed completely. Histological examinations after treatment revealed large necrotic areas close to particle deposits. These results suggest that hyperthermia using FA-PEI-MNPs is an effective and specific therapy for tumor. This therapy may provide an alternative way to treat recurrent cancer refractory to other modalities.
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
关键词[WOS]IRON-OXIDE NANOPARTICLES ; FOCUSED ULTRASOUND ABLATION ; TARGETED DRUG-DELIVERY ; ISSUE-ON REVIEWS ; BREAST-CANCER ; FOLIC-ACID ; BIOMEDICAL APPLICATIONS ; CATIONIC LIPOSOMES ; PROSTATE-CANCER ; NANOMATERIALS
语种英语
WOS记录号WOS:000387083900083
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260247
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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Zheng, WP,Rong, Z,Gao FP,et al. Folate-Conjugated Magnetic Nanoparticles for Tumor Hyperthermia Therapy: In Vitro and In Vivo Studies[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(8):8352-8359.
APA Zheng, WP.,Rong, Z.,高福平.,高学云.,高靓.,...&Tang, JT.(2016).Folate-Conjugated Magnetic Nanoparticles for Tumor Hyperthermia Therapy: In Vitro and In Vivo Studies.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(8),8352-8359.
MLA Zheng, WP,et al."Folate-Conjugated Magnetic Nanoparticles for Tumor Hyperthermia Therapy: In Vitro and In Vivo Studies".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.8(2016):8352-8359.
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