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Synthesis of a UCNPs@SiO2@gadofullerene nanocomposite and its application in UCL/MR bimodal imaging
Cheng Li(李成)1,2; Rongli Cui1; Juan Li1; Huan Huang1; Huanli Yao1,2; Xihong Guo1; Jinquan Dong1; Gengmei Xing1; Baoyun Sun(孙宝云)1
2016
发表期刊RSC Adv.
期号6页码:98968–98974
通讯作者Baoyun Sun(孙宝云)
摘要
Multimodal imaging provides more complementary information than single mode imaging. Herein, we have developed a novel bimodal imaging agent (GdF–UCNPs) through conjugating paramagnetic water-soluble polyhydroxy Gd@C82-PCBM with silica coated NaYF4:Yb,Er nanoparticles. In the new contrast agent, the stable silica shell and the carbon cage structure protect the encaged inner rare earth ions, which results in low toxicity. The resulting nanoconjugates exhibit strong luminescence and present efficient MRI contrast (r1 =11.89 mM-1 s-1). Ex vivo and in vivo bimodal imagings were carried out in a mouse model. The results prove that the nanocomposites are useful as bimodal imaging agents for luminescence/MR imaging in biomedical research.
学科领域化学 ; 无机化学 ; 生物无机化学
DOI10.1039/c6ra21295f
收录类别SCI
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260179
专题多学科研究中心
作者单位1.CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS)
2.University of Chinese Academy of Sciences
推荐引用方式
GB/T 7714
Cheng Li,Rongli Cui,Juan Li,et al. Synthesis of a UCNPs@SiO2@gadofullerene nanocomposite and its application in UCL/MR bimodal imaging[J]. RSC Adv.,2016(6):98968–98974.
APA Cheng Li.,Rongli Cui.,Juan Li.,Huan Huang.,Huanli Yao.,...&Baoyun Sun.(2016).Synthesis of a UCNPs@SiO2@gadofullerene nanocomposite and its application in UCL/MR bimodal imaging.RSC Adv.(6),98968–98974.
MLA Cheng Li,et al."Synthesis of a UCNPs@SiO2@gadofullerene nanocomposite and its application in UCL/MR bimodal imaging".RSC Adv. .6(2016):98968–98974.
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