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Immunostimulatory properties and enhanced TNF-alpha mediated cellular immunity for tumor therapy by C-60(OH)(20) nanoparticles
Liu, Y; Jiao, F; Qiu, Y; Li, W; Qu, Y; Tian, CX; Li, YF; Bai, R; Lao, F; Zhao, YL; Chai, ZF; Chen, CY; Zhao YL(赵宇亮); Chai ZF(柴之芳)
刊名NANOTECHNOLOGY
2009
卷号20期号:41页码:415102
学科分类Science & Technology - Other Topics; Materials Science; Physics
DOI10.1088/0957-4484/20/41/415102
通讯作者[Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Chen, Chunying] Natl Ctr Nanosci & Technol China, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
文章类型Article
英文摘要Publications concerning the mechanism of biological activity, especially the immunological mechanism of C-60(OH)(20) nanoparticles, are relatively limited. However, the structure and characteristics of this carbon allotrope have been widely investigated. In this paper, we have demonstrated that water-soluble C-60(OH)(20) nanoparticles have an efficient anti-tumor activity in vivo, and show specific immunomodulatory effects to the immune cells, such as T cells and macrophages, both in vivo and in vitro. For example, C-60(OH)(20) nanoparticles can increase the production of T-helper cell type 1 (Th1) cytokines (IL-2, IFN-gamma and TNF-alpha), and decrease the production of Th2 cytokines (IL-4, IL-5 and IL-6) in serum samples. On the other hand, C-60(OH)(20) nanoparticles show almost no adverse effect to the viability of immune cells in vitro but stimulate the immune cells to release more cytokines, in particular TNF-alpha, which plays a key role in the cellular immune process to help eliminate abnormal cells. TNF-alpha production increased almost three-fold in treated T lymphocytes and macrophages. Accordingly, we conclude that C-60(OH)(20) nanoparticles have an efficient anti-tumor activity and this effect is associated with an increased CD4+/CD8+ lymphocyte ratio and the enhancement of TNF-alpha production. The data suggest that C-60(OH)(20) nanoparticles can improve the immune response to help to scavenge and kill tumor cells.
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics
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语种英语
WOS记录号WOS:000269930100003
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被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/241061
专题院士_期刊论文
作者单位中国科学院高能物理研究所
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GB/T 7714
Liu, Y,Jiao, F,Qiu, Y,et al. Immunostimulatory properties and enhanced TNF-alpha mediated cellular immunity for tumor therapy by C-60(OH)(20) nanoparticles[J]. NANOTECHNOLOGY,2009,20(41):415102.
APA Liu, Y.,Jiao, F.,Qiu, Y.,Li, W.,Qu, Y.,...&柴之芳.(2009).Immunostimulatory properties and enhanced TNF-alpha mediated cellular immunity for tumor therapy by C-60(OH)(20) nanoparticles.NANOTECHNOLOGY,20(41),415102.
MLA Liu, Y,et al."Immunostimulatory properties and enhanced TNF-alpha mediated cellular immunity for tumor therapy by C-60(OH)(20) nanoparticles".NANOTECHNOLOGY 20.41(2009):415102.
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