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Lung deposition and extrapulmonary translocation of nano-ceria after intratracheal instillation
He X(何潇); Zhang HF(张海凤); Ma YH(马宇辉); Bai W(白伟); Zhang ZY(张智勇); Ding YY(丁雅韵); Zhao YL(赵宇亮); Chai ZF(柴之芳); He, XA; Zhang, HF; Ma, YH; Bai, W; Zhang, ZY; Lu, K; Ding, YY; Zhao, YL; Chai, ZF
2010
发表期刊NANOTECHNOLOGY
卷号21期号:28页码:285103
通讯作者[He, Xiao ; Zhang, Haifeng ; Ma, Yuhui ; Bai, Wei ; Zhang, Zhiyong ; Ding, Yayun ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Zhang, Haifeng] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China ; [Lu, Kai] S China Univ Technol, Sch Biol Sci & Engn, Guangzhou 510641, Peoples R China
文章类型Article
摘要The broad potential applications of manufactured nanomaterials call for urgent assessment of their environmental and biological safety. However, most of the previous work focused on the cell level performance; little was known about the consequences of nanomaterial exposure at the whole-body and organ levels. In the present paper, the radiotracer technique was employed to study the pulmonary deposition and the translocation to secondary target organs after ceria nanoparticles (nano-ceria) were intratracheally instilled into Wistar rats. It was found that 63.9 +/- 8.2% of the instilled nano-ceria remained in the lung by 28 d postexposure and the elimination half-life was 103 d. At the end of the test period, only 1/8-1/3 of the daily elimination of nano-ceria from the lung was cleared via the gastrointestinal tract, suggesting that phagocytosis by alveolar macrophages (AMs) with subsequent removal towards the larynx was no longer the predominant route for the elimination of nano-ceria from the lung. The whole-body redistribution of nano-ceria demonstrated that the deposited nano-ceria could penetrate through the alveolar wall into the systemic circulation and accumulate in the extrapulmonary organs. In vitro study suggested that nano-ceria would agglomerate and form sediments in the bronchoalveolar aqueous surrounding while binding to protein would be conducive to the redispersion of nano-ceria. The decrease in the size of agglomerates might enhance the penetration of nano-ceria into the systemic circulation. Our findings suggested that the effect of nanomaterial exposure, even at low concentration, should be assessed because of the potential lung and systemic cumulative toxicity of the nanomaterials.
学科领域Science & Technology - Other Topics; Materials Science; Physics
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics ; Science & Technology - Other Topics ; Materials Science ; Physics
DOI10.1088/0957-4484/21/28/285103
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语种英语
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000279259100003
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被引频次:80[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/241058
专题院士
加速器中心
多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
He X,Zhang HF,Ma YH,et al. Lung deposition and extrapulmonary translocation of nano-ceria after intratracheal instillation[J]. NANOTECHNOLOGY,2010,21(28):285103.
APA 何潇.,张海凤.,马宇辉.,白伟.,张智勇.,...&Chai, ZF.(2010).Lung deposition and extrapulmonary translocation of nano-ceria after intratracheal instillation.NANOTECHNOLOGY,21(28),285103.
MLA 何潇,et al."Lung deposition and extrapulmonary translocation of nano-ceria after intratracheal instillation".NANOTECHNOLOGY 21.28(2010):285103.
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