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Fullerene derivatives protect endothelial cells against NO-induced damage
Lao, F; Li, W; Han, D; Qu, Y; Liu, Y; Zhao, YL; Chen, CY; Li W(李炜); Zhao YL(赵宇亮); Chen CY(陈春英)
2009
发表期刊NANOTECHNOLOGY
卷号20期号:22页码:225103
通讯作者[Lao, Fang ; Han, Dong ; Qu, Ying ; Liu, Ying ; Zhao, Yuliang ; Chen, Chunying] Natl Ctr Nanosci & Technol China, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China ; [Li, Wei ; Zhao, Yuliang ; Chen, Chunying] Chinese Acad Sci, IHEP, CAS Key Lab Nucl Analyt Techn, Beijing 100049, Peoples R China
文章类型Article
摘要Functional fullerene derivatives have been demonstrated with potent antioxidation properties. Nitric oxide (NO) is a free radical that plays a part in leading to brain damage when it is accumulated to a high concentration. The possible scavenging activity of NO by the hydroxylated fullerene derivative C-60(OH)(22) and malonic acid derivative C-60(C(COOH)(2))(2) was investigated using primary rat brain cerebral microvessel endothelial cells (CMECs). Results demonstrate that sodium nitroprusside (SNP), used as an NO donor, caused a marked decrease in cell viability and an increase in apoptosis. However, fullerene derivatives can remarkably protect against the apoptosis induced by NO assault. In addition, fullerene derivatives can also prevent NO-induced depolymerization of cytoskeleton and damage of the nucleus and accelerate endothelial cell repair. Further investigation shows that the sudden increase of the intercellular reactive oxygen species (ROS) induced by NO was significantly attenuated by post-treatment with fullerene derivatives. Our results suggest that functional fullerene derivatives are potential applications for NO-related disorders.
学科领域Science & Technology - Other Topics; Materials Science; Physics
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics ; Science & Technology - Other Topics ; Materials Science ; Physics
DOI10.1088/0957-4484/20/22/225103
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语种英语
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000266045200003
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被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/241041
专题多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Lao, F,Li, W,Han, D,et al. Fullerene derivatives protect endothelial cells against NO-induced damage[J]. NANOTECHNOLOGY,2009,20(22):225103.
APA Lao, F.,Li, W.,Han, D.,Qu, Y.,Liu, Y.,...&陈春英.(2009).Fullerene derivatives protect endothelial cells against NO-induced damage.NANOTECHNOLOGY,20(22),225103.
MLA Lao, F,et al."Fullerene derivatives protect endothelial cells against NO-induced damage".NANOTECHNOLOGY 20.22(2009):225103.
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