Fullerene derivatives protect endothelial cells against NO-induced damage
Lao, F; Li, W; Han, D; Qu, Y; Liu, Y; Zhao, YL; Chen, CY; Li W(李炜); Zhao YL(赵宇亮); Chen CY(陈春英)
刊名NANOTECHNOLOGY
2009
卷号20期号:22页码:225103
学科分类Science & Technology - Other Topics; Materials Science; Physics
DOI10.1088/0957-4484/20/22/225103
通讯作者[Lao, Fang ; Han, Dong ; Qu, Ying ; Liu, Ying ; Zhao, Yuliang ; Chen, Chunying] Natl Ctr Nanosci & Technol China, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China ; [Li, Wei ; Zhao, Yuliang ; Chen, Chunying] Chinese Acad Sci, IHEP, CAS Key Lab Nucl Analyt Techn, Beijing 100049, Peoples R China
文章类型Article
英文摘要Functional fullerene derivatives have been demonstrated with potent antioxidation properties. Nitric oxide (NO) is a free radical that plays a part in leading to brain damage when it is accumulated to a high concentration. The possible scavenging activity of NO by the hydroxylated fullerene derivative C-60(OH)(22) and malonic acid derivative C-60(C(COOH)(2))(2) was investigated using primary rat brain cerebral microvessel endothelial cells (CMECs). Results demonstrate that sodium nitroprusside (SNP), used as an NO donor, caused a marked decrease in cell viability and an increase in apoptosis. However, fullerene derivatives can remarkably protect against the apoptosis induced by NO assault. In addition, fullerene derivatives can also prevent NO-induced depolymerization of cytoskeleton and damage of the nucleus and accelerate endothelial cell repair. Further investigation shows that the sudden increase of the intercellular reactive oxygen species (ROS) induced by NO was significantly attenuated by post-treatment with fullerene derivatives. Our results suggest that functional fullerene derivatives are potential applications for NO-related disorders.
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics
原文出处查看原文
语种英语
WOS记录号WOS:000266045200003
引用统计
被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/241041
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Lao, F,Li, W,Han, D,et al. Fullerene derivatives protect endothelial cells against NO-induced damage[J]. NANOTECHNOLOGY,2009,20(22):225103.
APA Lao, F.,Li, W.,Han, D.,Qu, Y.,Liu, Y.,...&陈春英.(2009).Fullerene derivatives protect endothelial cells against NO-induced damage.NANOTECHNOLOGY,20(22),225103.
MLA Lao, F,et al."Fullerene derivatives protect endothelial cells against NO-induced damage".NANOTECHNOLOGY 20.22(2009):225103.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
10260.pdf(1320KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lao, F]的文章
[Li, W]的文章
[Han, D]的文章
百度学术
百度学术中相似的文章
[Lao, F]的文章
[Li, W]的文章
[Han, D]的文章
必应学术
必应学术中相似的文章
[Lao, F]的文章
[Li, W]的文章
[Han, D]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 10260.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。