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The translocation of fullerenic nanoparticles into lysosome via the pathway of clathrin-mediated endocytosis
Li W(李炜); Chen CY(陈春英); Ye C(叶昶); Zhao YL(赵宇亮); Chen Z(陈真); Meng H(孟幻); Gao YX(高愈希); Yuan H(袁慧); Xing GM(邢更妹); Zhao F(赵峰); Chai ZF(柴之芳); Li, W; Chen, CY; Ye, C; Wei, TT; Zhao, YL; Lao, F; Chen, Z; Meng, H; Gao, YX; Yuan, H; Xing, GM; Zhao, F; Chai, ZF; Zhang, XJ; Yang, FY; Han, D; Tang, XH; Zhang, YG
2008
发表期刊NANOTECHNOLOGY
卷号19期号:14页码:145102
通讯作者[Li, Wei ; Chen, Chunying ; Ye, Chang ; Wei, Taotao ; Zhao, Yuliang ; Chen, Zhen ; Meng, Huan ; Gao, Yuxi ; Yuan, Hui ; Xing, Genmei ; Zhao, Feng ; Chai, Zhifang] Chinese Acad Sci, Natl Ctr Nanosci & Nanotechnol China, Lab Bio Environm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Li, Wei ; Chen, Chunying ; Ye, Chang ; Wei, Taotao ; Zhao, Yuliang ; Chen, Zhen ; Meng, Huan ; Gao, Yuxi ; Yuan, Hui ; Xing, Genmei ; Zhao, Feng ; Chai, Zhifang] Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Chen, Chunying ; Zhao, Yuliang ; Lao, Fang ; Han, Dong] Natl Ctr Nanosci & Technol China, Beijing 100080, Peoples R China ; [Wei, Taotao ; Zhang, Xujia ; Yang, Fuyu] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China ; [Tang, Xianhua ; Zhang, Yingge] Acad Mil Med Sci, Beijing 100039, Peoples R China ; [Li, Wei ; Lao, Fang ; Chen, Zhen ; Meng, Huan] Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China
文章类型Article
摘要Manufactured fullerene nanoparticles easily enter into cells and hence have been rapidly developed for biomedical uses. However, it is generally unknown which route the nanoparticles undergo when crossing cell membranes and where they localize to the intracellular compartments. Herein we have used both microscopic imaging and biological techniques to explore the processes of [C-60(C(COOH)(2))(2)](n) nanoparticles across cellular membranes and their intracellular translocation in 3T3 L1 and RH-35 living cells. The fullerene nanoparticles are quickly internalized by the cells and then routed to the cytoplasm with punctate localization. Upon entering the cell, they are synchronized to lysosome-like vesicles. The [C-60(C(COOH)(2))(2)](n) nanoparticles entering cells are mainly via endocytosis with time-, temperature-and energy-dependent manners. The cellular uptake of [C-60(C(COOH)(2))(2)](n) nanoparticles was found to be clathrin-mediated but not caveolae-mediated endocytosis. The endocytosis mechanism and the subcellular target location provide key information for the better understanding and predicting of the biomedical function of fullerene nanoparticles inside cells.
学科领域Science & Technology - Other Topics; Materials Science; Physics
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics ; Science & Technology - Other Topics ; Materials Science ; Physics
DOI10.1088/0957-4484/19/14/145102
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语种英语
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000254174500002
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被引频次:68[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/241004
专题院士
加速器中心
多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Li W,Chen CY,Ye C,et al. The translocation of fullerenic nanoparticles into lysosome via the pathway of clathrin-mediated endocytosis[J]. NANOTECHNOLOGY,2008,19(14):145102.
APA 李炜.,陈春英.,叶昶.,赵宇亮.,陈真.,...&Zhang, YG.(2008).The translocation of fullerenic nanoparticles into lysosome via the pathway of clathrin-mediated endocytosis.NANOTECHNOLOGY,19(14),145102.
MLA 李炜,et al."The translocation of fullerenic nanoparticles into lysosome via the pathway of clathrin-mediated endocytosis".NANOTECHNOLOGY 19.14(2008):145102.
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