[Chen, D. Y.
; Dong, Y. B.] Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China
; [Zhou, H. Q.] Southeast Univ, Dept Phys, Nanjing 211189, Peoples R China
We estimate the two-photon exchange contribution to the process e(+)+e(-)-> p+p . The two-photon exchange corrections to double spin polarization observables and form factors in the time-like region are calculated. The corrections are found to be small in magnitude but with a strong angular dependence at fixed momentum transfer. These two features are the same as those in the space-like region. In future experiments, the double spin polarization observable P(z) deserves to be considered.